Intravitreal Bevacizumab for Neovascular Glaucoma
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Les sponsors
Shahid Beheshti University of Medical Sciences
ESSAI CLINIQUE: NCT00384631
BioSeek: nct00384631
Mots clés
Abstrait
Several studies have confirmed high levels of vascular endothelial growth factor (VEGF) in eyes with neovascular glaucoma (NVG). The role of VEGF inhibitors in regression of other neovascular disorders such as wet-type age-related macular degeneration and diabetic macular edema has been described. We aim to evaluate the effect of three intravitreal injections of bevacizumab (Avastin) 2.5 mg versus a sham procedure for treatment of NVG. Outcome measures include intraocular pressure and extent of iris neovascularization. Both study arms will receive conventional treatment for NVG.
Rendez-vous
| Dernière vérification: | 01/31/2008 |
| Première soumission: | 10/03/2006 |
| Inscription estimée soumise: | 10/03/2006 |
| Première publication: | 10/05/2006 |
| Dernière mise à jour soumise: | 02/13/2008 |
| Dernière mise à jour publiée: | 02/14/2008 |
| Date de début réelle de l'étude: | 03/31/2006 |
| Date estimée d'achèvement de l'étude: | 02/28/2007 |
Condition ou maladie
Neovascular
Glaucoma
Intervention / traitement
Other: 2
Drug: 1
Phase
-
Groupes d'armes
| Bras | Intervention / traitement |
|---|---|
| Sham Comparator: 2 | Other: 2 0.1cc normal saline injection in the subconjunctival space repeated twice at monthly intervals |
| Experimental: 1 | Drug: 1 intravitreal injection of avastin 2.5mg repeated twice at monthly intervals |
Critère d'éligibilité
| Âges éligibles aux études | 10 Years À 10 Years |
| Sexes éligibles à l'étude | All |
| Accepte les bénévoles en santé | Oui |
| Critères | Inclusion Criteria: - Clinical diagnosis of NVG - Vision less than 20/200 - age 10-80 years Exclusion Criteria: - Uncontrolled Blood Pressure - History of thromboembolism - Congestive Heart Failure - Renal Failure - Pregnancy or Lactation - Active ocular or periocular infection - No light perception |
Résultat
Mesures des résultats primaires
1. Change in intraocular pressure [6 months]
2. Change in extent of iris neovascularization [6 months]
Mesures des résultats secondaires
1. Best corrected visual acuity [6 months]
