Ischemic Preconditioning at a Distance in Liver Surgery
Mots clés
Abstrait
Rendez-vous
Dernière vérification: | 10/31/2019 |
Première soumission: | 11/19/2019 |
Inscription estimée soumise: | 11/26/2019 |
Première publication: | 11/28/2019 |
Dernière mise à jour soumise: | 11/26/2019 |
Dernière mise à jour publiée: | 11/28/2019 |
Date de début réelle de l'étude: | 01/31/2020 |
Date d'achèvement primaire estimée: | 01/31/2021 |
Date estimée d'achèvement de l'étude: | 01/31/2021 |
Condition ou maladie
Intervention / traitement
Procedure: Inflation of a pneumatic tourniquet
Other: No inflation
Phase
Groupes d'armes
Bras | Intervention / traitement |
---|---|
Experimental: Inflation of a pneumatic tourniquet | Procedure: Inflation of a pneumatic tourniquet a pneumatic tourniquet around 200 mmHg after venous chase of the lower limb, during 5 minutes then deflated. Repeated twice after general anaesthesia and prior to incision. |
Sham Comparator: No inflation No inflation of the pneumatic tourniquet placed on the lower limb | Other: No inflation No inflation of the pneumatic tourniquet placed on the lower limb |
Critère d'éligibilité
Âges éligibles aux études | 18 Years À 18 Years |
Sexes éligibles à l'étude | All |
Accepte les bénévoles en santé | Oui |
Critères | Inclusion Criteria: - Scheduled carcinogenic laparoscopy or laparotomy liver resection - Insured under the social security system - Inclined to comply to the study protocol and its duration. Exclusion Criteria: - Patient under guardianship - Pregnancy or breastfeeding - Severe lower limb vascular disease - Emergency surgery - Contraindication of a treatment from the protocol - Psychological disorder with difficulty to accede the protocol - Absence of written informed consent - Refusal to sign the protocol - Non-registration to the social security system |
Résultat
Mesures des résultats primaires
1. Indocyanine green clearance [at 5 days after liver resection]
Mesures des résultats secondaires
1. Serum transaminases rates [at day 1,day 3 and day 5 post-hepatectomy.]
2. Prothrombin rate [at day 5 post-hepatectomy.]
3. the Kidney Disease: Improving Global Outcomes (KDIGO) score [at day 1,day 3 and day 5 post-hepatectomy.]
4. the Clavien & Dindo score [at day 30 post-hepatectomy]
5. duration of stay in the hospital. [at day 30 post-hepatectomy]