Antitubercular and cytotoxic polyoxygenated cyclohexane derivatives from Uvaria grandiflora.

Chromatographic purification of the DCM sub-extract of Uvaria grandiflora led to the isolation and characterization of a new polyoxygenated cyclohexane derivative, grandifloranol (1), together with five known compounds. Among the compounds isolated, zeylenone (3) showed moderate antitubercular activity against Mycobacterium tuberculosis H₃₇Rv with MIC₉₀ value of 51.2 μM and antiproliferative or cytotoxic activity against human myeloid leukaemia (K-562) and HeLa cells with IC₅₀ values of 2.3 and 18.3 μM, respectively.