The present invention relates to novel chromone alkaloid of formula 1 isolated from the plant Dysoxylum binectariferum. The compound 5,7-dihydroxy-6-(3-hydroxy-1-methylpiperidin-4-yl)-2-methyl-4H-chromen-4-- one, is found to be a potential inhibitor of cell growth and proliferation and also inhibits production of pro-inflammatory cytokines. The formulations of this particular compound can be used for treatment of cancer and inflammation. ##STR00001##

Council of Scientific &amp; Industrial Research

COUNCIL OF SCIENTIFIC &amp; INDUSTRIAL RESEARCH

Chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders

The present invention discloses eight new diterpenoids, i.e. Dysongensins A to H, extracted from the leaves and twigs of Dysoxylurn hongkongense, wherein AMBROX.RTM. which is applicable in the perfume industry is prepared from Dysongensin A via a series of chemical reactions, and the cytotoxicity of Dysongensins A to H against human cancer cell lines and their antiviral and anti-inflammatory activities are determined. Therefore, in the present invention, AMBROX.RTM. prepared from Dysongensin A is a new idea for application as an odorous compound in the perfume industry, and the novel diterpenoids can be prepared as a pharmaceutical compositions and/or a drug having antiviral, anti-inflammatory and/or anti-cancer activities.

National Taiwan University

dysoxylum ficiforme/inflammation

Chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders

Preparation of ambrox from labdanes of Dysoxylum hongkongense, and the preparation of new diterpenoids from Dysoxylum hongkongense

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