Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein: A is a bond or --OCH.sub.2 --, where the oxygen is linked to R.sup.1 ;B is --CH.sub.2 -- or when R.sup.3 is hydrogen, B may be --CH.sub.2 O-- where the oxygen is linked to the phenyl ring;R.sup.1 is an aryl group;R.sup.2 is hydrogen or lower alkyl;R.sup.3 is hydrogen; or R.sup.2 and R.sup.3 together form the group --CH.sub.2 CH.sub.2 --; andR.sup.4 is --SO.sub.3 H, --P(O.sub.2 H)R.sup.5, --P(O.sub.2 R.sup.5')R.sup.5, --PO.sub.3 H.sub.2, --PO.sub.3 HR.sup.5' or --PO.sub.3 (R.sup.5').sub.2 where R.sup.5 and R.sup.5' are independently lower alkyl. These compounds are beta.sub.3 adrenergic receptor agonists and are useful, for example, in the treatment of diabetes, obesity, achalasia, and gastrointestinal diseases.

Bristol-Myers Squibb Company

Sulfonic, phosphonic or phosphiniic acid .beta..sub.3 agonist derivatives

Compounds are provided having the formula ##STR1##including pharmaceutically acceptable salts thereof, whereinR.sup.1 is lower alkyl, aryl or arylalkyl;A is hydrogen or ##STR2##B is hydrogen, alkyl, alkenyl, or ##STR3##but when A is hydrogen, B may only be ##STR4##R.sup.2, R.sup.2', R.sup.2", R.sup.3 R.sup.3' and R.sup.3" are as defined herein;m is 0-3. These compounds possess activity at the beta 3 adrenergic receptor in mammals and are useful in the treatment of diabetes, obesity, depression, achalasia and intestinal hypermotility disorders.

2-hydroxy-3--(4-hydroxy-3-sulfonamidophenyl)--propylamines useful as beta 3 adrenergic agonists

Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein: R.sup.1 to R.sup.9 are as defined herein and m is the integer 0 or 1.These compounds are beta 3 adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity, gastrointestinal diseases and achalasia.

Aryloxypropanolamine beta 3 adrenergic agonists

Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein: R.sup.1 to R.sup.9 are as defined herein and m is the integer 0 or 1. These compounds are beta 3 adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity, gastrointestinal diseases and achalasia.

esophageal achalasia/obésité

Sulfonic, phosphonic or phosphiniic acid .beta..sub.3 agonist derivatives

2-hydroxy-3--(4-hydroxy-3-sulfonamidophenyl)--propylamines useful as beta 3 adrenergic agonists

Aryloxypropanolamine beta 3 adrenergic agonists

Aryloxypropanolamine .beta. 3 adrenergic agonists

La base de données d'herbes médicinales la plus complète soutenue par la science