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esophagitis/céphalée
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Long-term efficacy of lansoprazole in preventing relapse of erosive reflux esophagitis.
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In a phase III study of lansoprazole treatment, patients with healed or unhealed erosive esophagitis entered a titrated open-label treatment period and received lansoprazole for
The clinical safety of long-term lansoprazole for the maintenance of healed erosive oesophagitis.
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BACKGROUND
The clinical safety of long-term lansoprazole therapy for the maintenance of healed erosive oesophagitis has not been extensively studied in clinical trials.
OBJECTIVE
To assess the long-term clinical safety of dose-titrated lansoprazole as maintenance therapy for up to 82 months in
Comparable clinical efficacy and tolerability of 20 mg pantoprazole and 20 mg omeprazole in patients with grade I reflux oesophagitis.
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BACKGROUND
Several clinical trials have shown that pantoprazole (40 mg) and omeprazole (40 or 20 mg) have similar efficacy and safety in the treatment of grade II-IV reflux oesophagitis (Savary-Miller classification).
OBJECTIVE
To compare the efficacy and safety of once-daily doses of pantoprazole
Medical treatments for the maintenance therapy of reflux oesophagitis and endoscopic negative reflux disease.
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BACKGROUND
Gastro-oesophageal reflux disease (GORD) - reflux of stomach contents +/- bile into the oesophagus causing symptoms such as heartburn and acid reflux - is a common relapsing and remitting disease which often requires long-term maintenance therapy. Patients with GORD may have oesophagitis
WITHDRAWN: Medical treatments for the maintenance therapy of reflux oesophagitis and endoscopic negative reflux disease.
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BACKGROUND
Gastro-oesophageal reflux disease (GORD) - reflux of stomach contents +/- bile into the oesophagus causing symptoms such as heartburn and acid reflux - is a common relapsing and remitting disease which often requires long-term maintenance therapy. Patients with GORD may have oesophagitis
Esomeprazole improves healing and symptom resolution as compared with omeprazole in reflux oesophagitis patients: a randomized controlled trial. The Esomeprazole Study Investigators.
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BACKGROUND
The pharmacologic profile of the new proton pump inhibitor esomeprazole has demonstrated advantages over omeprazole that suggest clinical benefits for patients with acid-related disease.
METHODS
1960 patients with endoscopy-confirmed reflux oesophagitis (RO) were randomized to once daily
Safety and efficacy of long term esomeprazole therapy in patients with healed erosive oesophagitis.
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OBJECTIVE
To evaluate the safety and tolerability of long term treatment with esomeprazole in patients with healed erosive oesophagitis, and to describe its efficacy in the maintenance of healing.
METHODS
US multicentre, noncomparative, nonblind study.
METHODS
807 patients with endoscopically
Onset of symptom relief with rabeprazole: a community-based, open-label assessment of patients with erosive oesophagitis.
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BACKGROUND
In numerous clinical trials, proton pump inhibitors have demonstrated potent acid suppression and healing of erosive oesophagitis, as well as successful symptom relief for the entire spectrum of gastro-oesophageal reflux disease.
OBJECTIVE
The 'Future of Acid Suppression Therapy' (FAST)
Rapid symptom relief in reflux oesophagitis: a comparison of lansoprazole and omeprazole.
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BACKGROUND
Lansoprazole, a substituted benzimidazole, is a proton pump inhibitor which is highly effective in the control of 24-h intragastric acidity. The aim of this multicentre, randomized, double-blind study was to compare lansoprazole 30 mg once daily and omeprazole 20 mg once daily in the
Dual Delayed-Release Dexlansoprazole for Healing and Maintenance of Healed Erosive Esophagitis: A Safety Study in Adolescents.
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BACKGROUND
In gastroesophageal reflux disease (GERD), the frequency of heartburn symptoms and erosive esophagitis (EE) increases with age in children and adolescents. Proton pump inhibitor, dexlansoprazole, is approved for healing EE of all grades, maintenance of healed EE, relief of heartburn, and
Efficacy and tolerability of pantoprazole versus ranitidine in the treatment of reflux esophagitis and the influence of Helicobacter pylori infection on healing rate.
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Patients with reflux esophagitis (grade II or III, Savary-Miller, intention-to-treat, n=256, age range 19-82 years) were randomly assigned to a double-blind, double-dummy treatment with either pantoprazole 40 mg once daily or ranitidine 150 mg twice daily. After 4 weeks, each patient was clinically
Esomeprazole in acute and maintenance treatment of reflux oesophagitis: a multicentre prospective study.
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BACKGROUND
The aim of this study was to assess the efficacy and safety of esomeprazole 40 mg once daily (q.d.) in healing reflux oesophagitis at 4 and 8 weeks, and the efficacy of esomeprazole 20 mg q.d. for 12 weeks in the maintenance of remission.
METHODS
A total of 235 patients with
Association of esophagitis and esophageal strictures with diseases treated with nonsteroidal anti-inflammatory drugs.
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BACKGROUND
It has been speculated that intake of nonsteroidal anti-inflammatory drugs (NSAIDs) represents a risk factor for the occurrence of esophagitis and esophageal strictures.
METHODS
A case-control study was conducted to compare the occurrence of comorbid diseases treated with NSAIDs in case
Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial.
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BACKGROUND
Eosinophilic esophagitis is a chronic allergic disease with insufficient treatment options. Results from animal studies suggest that IL-5 induces eosinophil trafficking in the esophagus.
OBJECTIVE
We sought to evaluate the effect of reslizumab, a neutralizing antibody against IL-5, in
Efficacy and safety of esomeprazole compared with omeprazole in GERD patients with erosive esophagitis: a randomized controlled trial.
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OBJECTIVE
In patients with gastroesophageal reflux disease (GERD), esomeprazole, the S-isomer of omeprazole, has demonstrated pharmacological and clinical benefits beyond those seen with the racemic parent compound. This study was designed to further evaluate the efficacy and tolerability of
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