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iris/scopolamine
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Acute effects of cholinesterase inhibitors on uptake of choline in the rat iris.
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The choline uptake system has been characterized in the albino rat iris. The isolated iris of the rat accumulates choline (Ch) by a high affinity (Km = 3.23 microM) and a low affinity (Km = 68.4 microM) process. The uptake of 1 microM Ch at 37 degrees C was inhibited in a dose-dependent manner by
Amitriptyline and imipramine inhibit the release of acetylcholine from parasympathetic nerve terminals in the rat iris.
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The electrically stimulated release of [3H]acetylcholine from the parasympathetic nerve terminals of the rat iris in vitro is increased in a dose-dependent manner by scopolamine but is decreased by the tricyclic antidepressants amitriptyline and imipramine. The increased release in the presence of
Action of Hydrobromate of Scopolamine upon the Iris and Ciliary Muscle-Hypnotic Anæsthesia-Turck's Gyromele in the Diagnosis and Treatment of Diseases of the Stomach-Europhen-A Simple Remedy for Enuresis.
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The relative potencies of cholinomimetics and muscarinic antagonists on the rat iris in vivo: effects of pH on potency of pirenzepine and telenzepine.
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The effects of cholinomimetics and muscarinic antagonists were compared following topical administration to the eyes of anaesthetized rats. For tests with cholinomimetics, clonidine (0.3 mg/kg) was used to induce mydriasis via central inhibition of parasympathetic tone. Full, dose-dependent miosis
Secretin and insulin: response to intraduodenal acid.
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Immunoreactive secretin (IRS) and immunoreactive insulin (IRI) levels were measured in humans and dogs following the intraduodenal instillation of hydrochloric acid. IRS levels rose after acid in both instances, but a concomitant rise in peripheral IRI levels was not noted. Premedication of the
Anisocoria associated with the medical treatment of irritable bowel syndrome.
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A case of anisocoria associated with oral pharmacologic treatment of irritable bowel syndrome is reported. A 26-year-old woman developed sudden onset of anisocoria and compromised accommodation that lasted 2 days after the use of oral scopolamine methylbromide for treatment of irritable bowel
[Secondary pigment dispersion syndrome following 24 years of medically induced mydriasis (author's transl)].
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A 59-year-old male patient with congenital central cataract was treated for 24 years with atropine, scopolamine, and thyramine hydrochloride eye drops to achieve a permanent mydriasis for optical reasons. He developed a peculiar secondary pigment dispersion syndrome, which is interpreted as a
Pupillographic analysis of morphine action in the rabbit: role to the autonomic nervous system.
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Pupillary response of albino rabbits were recorded using an infrared video pupillometer. The transient response to an i.v. injection of morphine (1-12 mg/kg) consists of three phases. Phase 1 is a brief mydriasis of 20 s duration. Phase 2 is a miosis that reaches a maximum within 2-4 min and is the
[Mydriasis caused by plant contact].
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Uni- or bilateral dilatation of pupils that are not reactive to light and lack miosis in response to 1% pilocarpine may be caused by contact with plants containing alkaloids such as scopolamine and atropine. Other causes of a non-light-reactive dilated pupil, such as Adie's tonic pupil, third nerve
[6 beta-acetoxy nortropane and its muscarinic receptor kinetics].
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Bao gong teng A (BGT-A), a cholinergic tropane, was first separated from Erycibe obtusifolia Benth in China in 1978. 6 beta-Acetoxy nortropane (6 beta-AN), a new tropane analogue of BGT-A, was synthesized in 1983, in our university. Tropanes are generally known as M-cholinoceptor blockers, but 6
Probing peripheral and central cholinergic system responses.
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OBJECTIVE
The pharmacological response to drugs that act on the cholinergic system of the iris has been used to predict deficits in central cholinergic functioning due to diseases such as Alzheimer's disease, yet correlations between central and peripheral responses have not been properly studied.
Parameters of drug antagonism: re-examination of two modes of functional competitive drug antagonism on intraocular muscles.
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There are two distinct kinetic functional pharmacological procedures by which the equilibrium affinity constant, KB, of a competitive reversible blocker is obtained. The classical method on an organ system requires the study of the parallel displacement of the agonist concentration-response curve in
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