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Malignant hyperthermia caused by intravenous lidocaine for ventricular arrhythmia.
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We encountered a case of malignant hyperthermia caused by intravenous lidocaine which had been administered as treatment for a ventricular arrhythmia. The patient, a 72-year-old male, was admitted with chronic renal failure and aortic valvular stenosis. His chronic renal failure progressed, and
Reduction of pain and local complications when buffered lidocaine solution is used as a local anesthetic in conjunction with hyperthermia treatments: results of a randomized trial.
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Unbuffered lidocaine (pH = 6.5) is commonly employed as a local anesthetic prior to transcutaneous placement of catheters for use in temperature monitoring during hyperthermia treatments. The most frequent complaint associated with this procedure is stinging or burning pain at the injection site.
[Unknown fever and abnormal liver functions after repeated epidural blocks with lidocaine for management of herpes zoster pain].
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We present a case of unknown fever and abnormal liver functions which developed during the course of pain management for herpes zoster with repeated epidural blocks with 0.5% lidocaine 10 ml. The patient was a 67 year old woman. At her first admission to dermatology, there were no abnormal findings
Structural changes in murine cancer associated with hyperthermia and lidocaine.
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Hyperthermia alone and hyperthermia with lidocaine cause changes in the fine structure of the CA755 tumor cell as well as the breakdown of the tumor vasculature. The first structural change, observed immediately after termination of hyperthermia of 43.5 degrees for 1 hr, is the vesiculation of the
Failure of lidocaine to trigger porcine malignant hyperthermia.
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Lidocaine, considered by some to be potentially dangerous in malignant hyperthermia (MH), was administered intravenously to a dose of 15 mg/kg to five conscious MH-susceptible pigs. Subsequently the same pigs were given 24 mg/kg intravenously over a period of 2 hours after being anesthetized with
[Efficacy of lidocaine cream in protecting against thermal stress during hyperthermia].
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Hyperthermia is performed in combination with chemotherapy as multimodal treatment for recurrent and advanced cancer. It is generally believed that the temperature cannot be raised higher because of thermal stress. In this study, we examined the efficacy of lidocaine cream in protecting against
Systemic lidocaine enhancement of hyperthermia-induced tumor regression in transplantable murine tumor models.
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Previously, we reported that local lidocaine infusion of a CA 755 mammary adenocarcinoma growing in C57BL X DBA/2 F1 mice, when combined with local heating for 1 hr in a 43.5 degrees water bath, significantly increased survival and inhibited tumor growth more than heating alone. Because of its
[Study on enhancement of the permeability of drugs to the wall of the urinary bladder by hyperthermia with lidocaine].
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Lidocaine a safe agent to use for dysrhythmias during a malignant hyperthermia crisis.
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A case of malignant hyperthermia during epidural analgesia.
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Malignant hyperthermia syndrome developed during epidural analgesia in 25-year-old female to be operated on for haemorrhoidal varices. After premedication with diazepam and atropine epidural analgesia was started with lidocaine 300 mg and bupivacaine 50 mg. Signs and symptoms of malignant
Chemoembolization for hepatocellular carcinoma: effect of intraarterial lidocaine in peri- and post-procedural pain and hospitalization.
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OBJECTIVE
To assess the efficacy of intraarterial lidocaine on peri- and post-procedural pain and on length of hospital stay in hepatocellular carcinoma (HCC) patients undergoing chemoembolization.
METHODS
Twenty-eight patients (19M, 9F, age range 49-76) who underwent hepatic chemoembolization at
Selective enhancement of the cytotoxicity of the bleomycin derivative, peplomycin, by local anesthetics alone and combined with hyperthermia.
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The effect of local anesthetics alone and combined with hyperthermia on the cytotoxic effect of the bleomycin derivative, peplomycin, was studied in FM3A and HeLa cells. Noncytotoxic doses of the local anesthetics procaine, lidocaine, butacaine, tetracaine, and dibucaine enhanced peplomycin
Myotoxicity of local anesthetics is equivalent in individuals with and without predisposition to malignant hyperthermia.
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OBJECTIVE
Malignant hyperthermia (MH) is an inherited muscle disorder caused by abnormal elevations of intracellular calcium (Ca2+) in skeletal muscle. There are several reports of myotoxicity caused by local anesthetics, and the increased intracellular Ca2+ is considered to be an important cause.
What is the role of lidocaine or phenytoin in tricyclic antidepressant-induced cardiotoxicity?
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BACKGROUND
Tricyclic antidepressant (TCA) poisoning is a relatively common occurrence and remains a significant cause of mortality and morbidity. Deaths from TCA toxicity are typically due to cardiovascular events such as arrhythmias and hypotension. Cardiovascular toxicity may be multifactorial.
[Antiarrhythmic therapy in extreme conditions of artificial whole-body hyperthermia and artificial hyperglycemia in cancer patients].
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It has been shown that sessions of total body hyperthermia (rectal temperature - 40.0-41.8 degrees C) and artificial hyperglycemia (22-23 mmol/l) in combination with chemotherapy in cancer patients with severe cardiac arrhythmias should follow antiarrhythmic pretreatment and should be accompanied by
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