Derivatives of prednisolone of the formula ##STR1## wherein CR.sub.1 is C.dbd.O, .alpha.-HCOH, .beta.-HCOH, or a mixture of .alpha.-HCOH and .beta.-HCOH CR.sub.2 is HC(OH) OR.sub.6 or HCO when CR.sub.1 is C.dbd.O;CR.sub.2 is COOR.sub.3 or CONHR.sub.4 when CR.sub.1 is .alpha.-HCOH, .beta.-HCOH, or a mixture of .alpha.-HCOH and .beta.-HCOH:R.sub.3 is alkyl of 1-5 carbon atoms;R.sub.4 is alkyl of 1-5 carbon atoms, benzyl, or phenethyl;R.sub.5 is hydrogen, acetyl, or benzoyl;R.sub.6 is alkyl of 1-5 carbon atoms;R.sub.7 is .alpha.- or .beta.-position of hydrogen, hydroxyl, methyl, acetate esters of 1-5 carbon atoms, or alkoxy of 1-5 carbon atoms; andX and Y are hydrogen, halogen or methyl;and process for preparing these compounds. The compounds are useful as anti-inflammatory agents which have reduced side effects.

Florida Agricultural and Mechanical University

Anti-inflammatory prednisolone steroids

An in situ film-forming sprayable methyl acetate-based solution of at least one absorbable, low-crystallinity, segmented copolymer contains at least one bioactive agent, which exhibits antimicrobial, anti-inflammatory, antiviral, anesthetic, hemostatic, and/or antineoplastic activity. The absorbable polymers can be a polyaxial copolyester, polyether-ester and polyether-ester urethane and the bioactive solution thereof can be applied onto animal and human skin or accessible body cavities to prevent or treat one or more disorder susceptible to the bioactive agent therein.

Poly-Med, Inc.

In situ-formed bioactive tissue adherent films of absorbable crystallizable polymers

Shalaby; Shalaby W.

Corbett; Joel T.

Olbrich; Jason M.

An in situ film-forming methyl acetate-based solution of at least one absorbable, segmented block copolymer with amorphous and semi-crystalline segments contains at least one bioactive agent which exhibits antimicrobial, anti-inflammatory, antiviral, anesthetic, hemostatic, and/or antineoplastic activity. The absorbable polymers can be a polyaxial copolyester, polyether-ester and polyether-ester urethane. The solution can be applied (e.g., sprayed or swabbed) onto animal and human skin or accessible body cavities to prevent or treat one or more disorders preventable or treatable by the bioactive agent therein.

methyl acetate/inflammation

Anti-inflammatory prednisolone steroids

In situ-formed bioactive tissue adherent films of absorbable crystallizable polymers

In situ-formed bioactive tissue adherent films of absorbable crystallizable polymers

In situ film-forming bioactive solutions of absorbable multiblock copolymers

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