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mulberrofuran c/mûrier
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Mulberry Diels-Alder adducts: synthesis of chalcomoracin and mulberrofuran C methyl ethers.
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The synthesis of each of the heptamethyl ethers of the mulberry Diels-Alder adducts chalcomoracin (1) and mulberrofuran J (2) is described. The key steps in each approach involved a biomimetic intermolecular [4+2]-cycloaddition between a dehydroprenylphenol diene derived from an
Isoprenylated flavonoids from the root bark of Morus alba and their hepatoprotective and neuroprotective activities.
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A new isoprenylated flavonoid, 2S-5,7,2',4'-tetrahydroxy-3',5'-di-(γ,γ-dimethylallyl)flavanone, sanggenol Q (1), along with seven known isoprenylated flavonoids, sanggenol A (2), sanggenol L (3), kuwanon T (4), cyclomorusin (5), sanggenon F (6), sanggenol O (7), and sanggenon N (8), three known
[Chemical constituents from root barks of Morus atropurpurea].
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OBJECTIVE
To study the chemical constituents from the root barks of Morus atropurpurea.
METHODS
The chemical constituents from the 70% ethanol extract of M. atropurpurea were isolated and purified by column chromatographic methods. Their structures were identified by physico-chemical properties as
Constituents of the cultivated mulberry tree.
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In addition to mulberrofuran C, a new 2-arylbenzofuran derivative, six flavonoid derivatives, cyclomorusin, morusin, kuwanon C, E, G and H, as well as a known 2-arylbenzofuran derivative, chalcomoracin, were isolated from extracts of root bark of the cultivated mulberry tree (a variety of Morus
Mulberry Diels-Alder-type adducts from Morus alba as multi-targeted agents for Alzheimer's disease.
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Mulberry Diels-Alder-type adducts (MDAAs) are a group of structurally unique natural products biosynthetically derived from the intermolecular [4 + 2] cycloaddition of a dehydroprenylphenol and a chalcone. In the current study, ten MDAAs, including an undescribed one, inethermulberrofuran C, were
Protein tyrosine phosphatase 1B inhibitors from Morus root bark.
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An organic layer prepared from the Chinese crude drug 'Sang-Bai-Pi' (Morus root bark) was studied in order to identify the inhibitory compounds for protein tyrosine phosphatase 1B (PTP1B). Bioassay-guided fractionation resulted in the isolation of sanggenon C (1), sanggenon G (2), mulberrofuran C
Synthetic studies towards the mulberry Diels-Alder adducts: H-bond accelerated cycloadditions of chalcones.
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The methyl ether derivatives 2, 4 and 6 of the mulberry Diels-Alder adducts chalcomoracin (1) and mulberrofuran C (3) and kuwanon J (5) respectively have been synthesized by a thermal [4 + 2]-cycloaddition reaction between a chalcone and dehydroprenyl diene. A H-bonded ortho OH substituent on the
Anti-HSV Activity of Kuwanon X from Mulberry Leaves with Genes Expression Inhibitory and HSV-1 Induced NF-κB Deactivated Properties.
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Six stilbene derivatives isolated from Mulberry leaves including Kuwanon X, Mulberrofuran C, Mulberrofuran G, Moracin C, Moracin M 3'-O-b-glucopyranoside and Moracin M were found to have antiviral effects against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) at different potencies except for
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