Homocysteine After Laparoscopic Roux-enY Gastric Bypass
Keywords
Coimriú
Cur síos
Homocysteine is an independent risk factor for cardiovascular disease. Changes in homocysteine levels following bariatric surgery remain controversially discussed.
708 consecutive patients underwent laparoscopic roux-en-Y gastric bypass over a 6 year period. Throughout their routine follow-up, demographic data as well as homocysteine, folate and vitamin B12 were retrospectively collected at the timepoints: preoperatively, at 3, 6, 9, 12, 18, 24, 36, 48, 60, 72, 84, and 96 months postoperatively.
In order to reveal clinical relevance of the results, patients were sent a special questionnaire accompanied by an informed consent form for participation and asked for cardiovascular disease events (myocardial infarction, stroke, deep venous thrombosis) or any other hospital stay after the surgery and cross checked with two region wide databases which account for approx. 80% of all hospital contacts in the region. Additionally, the database was networked with the statewide death registry in order to reveal deceased subjects and data about their demise through the beforementioned databases was collected.
Dátaí
| Fíoraithe Deireanach: | 02/28/2018 |
| Cuireadh isteach den chéad uair: | 02/21/2018 |
| Clárú Measta Curtha isteach: | 03/28/2018 |
| Arna chur suas ar dtús: | 04/04/2018 |
| Nuashonrú Deireanach Curtha isteach: | 03/28/2018 |
| Nuashonrú Deireanach Postáilte: | 04/04/2018 |
| Dáta Tosaigh an Staidéir Iarbhír: | 04/08/2013 |
| Dáta Críochnaithe Bunscoile Measta: | 09/10/2017 |
| Dáta Críochnaithe an Staid Mheasta: | 09/10/2017 |
Coinníoll nó galar
Idirghabháil / cóireáil
Procedure: RYGB Patients
Céim
Grúpaí Láimhe
| Lámh | Idirghabháil / cóireáil |
|---|---|
| RYGB Patients Laparoscopic long limb roux-en-Y gastric bypass group. All consecutive patients eligible for bariatric surgery. | Procedure: RYGB Patients standard laparoscopic roux-en-Y gastric bypass (biliopancreatic limb 40 to 60 cm, alimentary limb 150 cm) |
Critéir Incháilitheachta
| Aois Incháilithe le haghaidh Staidéir | 18 Years Chun 18 Years |
| Gnéas Incháilithe le haghaidh Staidéir | All |
| Modh samplála | Non-Probability Sample |
| Glacann Oibrithe Deonacha Sláintiúla | Sea |
| Critéir | Inclusion Criteria: - BMI > 40kg/m2 or BMI > 35 kg/m2 including relevant comorbidities - Age between 18 to 75 years - suitable for operation, consent - no contraindications for the operation Exclusion Criteria: - BMI < 35 kg/m2 - age below 18 or above 75 years - not able to consent to the operation - severe medical conditions not applicable for general anaesthesia - non compliance |
Toradh
Bearta Toraidh Príomhúla
1. Homocysteine in µmol/l assessed by CMIA technique. [timepoints: preoperatively, 3, 6, 9, 12, 18, 24, 36, 48, 60, 72, and 96 months postoperatively]
Bearta Torthaí Tánaisteacha
1. Weight in kg measured by a standard scale. [timepoints: preoperatively, 3, 6, 9, 12, 18, 24, 36, 48, 60, 72, and 96 months postoperatively]
2. Folate in nmol/l assessed by ELCIA method. [timepoints: preoperatively, 3, 6, 9, 12, 18, 24, 36, 48, 60, 72, and 96 months postoperatively]
3. Vitamin B12 in pmol/l assessed by CMIA technique. [timepoints: preoperatively, 3, 6, 9, 12, 18, 24, 36, 48, 60, 72, and 96 months postoperatively]
4. Number of cardiovascular events assessed by a questionnaire and cross checking with 2 state wide databases. [Through study attendance the specific date of the incident was assessed and assigned to the timepoints: preoperatively, 3, 6, 9, 12, 18, 24, 36, 48, 60, 72, and 96 months postoperatively]
