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The Effect of Berries on Lung Cancer Tumors

Ní féidir ach le húsáideoirí cláraithe ailt a aistriú
Logáil Isteach / Cláraigh
Sábháiltear an nasc chuig an gearrthaisce
StádasFoirceanta
Urraitheoirí
University of Louisville
Comhoibritheoirí
James Graham Brown Cancer Center

Keywords

Coimriú

The purpose of this study is to determine how berries affect cancer tumors in patients with non-small cell lung cancer.

Cur síos

In the United States, more people (161,840 per year) die of lung cancers than of prostate cancer, breast cancer and colon cancer combined. Presently, there are over 43 million current smokers and over 47 million ex-smokers living in the US. Due to the lag time between smoking and the development of cancer, there are significant numbers of ex-smokers and current smokers who may develop lung cancer compared to never smokers.

Recent studies in animals have shown that berries, given as a dietary supplement, are highly effective against certain types of cancers. In a study involving mice with lung tumors, mice that had consumed a mixture of berries developed fewer tumors and had less tumor growth than mice that did not consume berries.

The berries used in this study will consist of blueberries, black raspberries, or a mixture of both.

Dátaí

Fíoraithe Deireanach: 01/31/2018
Cuireadh isteach den chéad uair: 05/18/2008
Clárú Measta Curtha isteach: 05/19/2008
Arna chur suas ar dtús: 05/20/2008
Nuashonrú Deireanach Curtha isteach: 02/02/2018
Nuashonrú Deireanach Postáilte: 02/05/2018
Dáta Tosaigh an Staidéir Iarbhír: 03/31/2008
Dáta Críochnaithe Bunscoile Measta: 11/30/2013
Dáta Críochnaithe an Staid Mheasta: 11/30/2013

Coinníoll nó galar

Non Small Cell Lung Cancer

Idirghabháil / cóireáil

Dietary Supplement: berry powder

Céim

-

Critéir Incháilitheachta

Aois Incháilithe le haghaidh Staidéir 18 Years Chun 18 Years
Gnéas Incháilithe le haghaidh StaidéirAll
Glacann Oibrithe Deonacha SláintiúlaSea
Critéir

Inclusion Criteria (lung cancer survivors):

- men treated for lung cancer, women treated for lung cancer and with no child-bearing potential (hysterectomy, tubal ligation, post-menopausal women)

Exclusion Criteria (lung cancer survivors):

- women who are on hormone replacement therapy

- women who are pregnant, or planning for pregnancy

- history of lung transplant

- prison inmate

- inability to take oral medication or food

- known or suspected allergy to berries or berry products

- HIV patients

Inclusion Criteria (volunteers):

- adult men, adult women with no child bearing potential (hysterectomy, tubal ligation, post-menopausal women)

Exclusion Criteria (volunteers):

- women who are on hormone replacement therapy

- women who are pregnant, or planning for pregnancy

- history of lung transplant

- prison inmate

- inability to take oral medication or food

- known or suspected allergy to berries or berry products

- HIV patients

Toradh

Bearta Toraidh Príomhúla

1. Assessment of blueberry and black raspberry phenolics in plasma and urine [upon completion of 4 to 5 weeks of daily consumption of berry powder]

In addition to determining the berry phytochemical profile in plasma and urine, this study will attempt to establish the effect of berries on modulating immunological profiles such as the complete blood count, and T, B and natural killer (NK) cell populations and circulating biomarkers (serum proteins and microRNAs). This pilot study will establish the safety and feasibility of conducting a larger clinical trial with berry intervention.

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