shanzhiside

Multiple carboxylase deficiency is a form of metabolic disorder involving failures of carboxylation enzymes.

The deficiency can be in biotinidase or holocarboxylase synthetase.These conditions respond to biotin.Forms include:

Holocarboxylase synthetase deficiency - neonatal;

Biotinidase deficiency - late onset;If left untreated, the symptoms can include feeding problems, decreased body tone, generalized red rash with skin exfoliation and baldness, failure to thrive, seizure, coma, developmental delay, ...