[Analysis of fetal distress in pregnancy with hepatitis B virus infection].

OBJECTIVE

To investigate the cause, prognosis and the treatment of fetal distress in pregnant women with hepatitis B virus (HBV) infection.

METHODS

eighty one pregnant women and their newborns were selected. The HBV surface antigen (HBsAg), e antigen (HBeAg), core antibody (HBcAb) and deoxyribonucleic acid (HBV DNA) was positive and the hepatic function normal. eighty five pregnant women without HBV infection, normal hepatic function and their newborns were collected as control. The clinical data, serology examination, placenta histological examination and fetal prognosis of the two groups was analysed 76 infants of the investigation group were vaccinated hepatitis B vaccine 10 microgram at 0, 1 and 6 month respectively. Infant's hepatitis B surface antibody (HBsAb) was detected at 24 month.

RESULTS

(1) The incidence of the fetal distress in investigation group was 38.3, %, in the control group was 16.5% (P < 0.05). (2) The main reason was chorion angiopathy induced by HBV infection of placenta. (3) In infants with fetal distress, the block rate from mother to fetus was 78.6%, for the infants without distress was 91.7% (P < 0.05).

CONCLUSIONS

HBV infection during pregnancy may cause placenta chorion angiopathy, reduce placenta function, lead to fetal distress and result in immunization failure.