[Cycloartane triterpenoid of Cimicifuga foetida].

OBJECTIVE

To study cycloartane triterpenoid of Cimicifuga foetida and their osteoclast inhibition activity.

METHODS

The compounds were isolated and purified by normal and reversed phase column chromatographic methods. Structures were identified by spectroscopic analyses. Their osteoclast inhibition activity was then studied.

RESULTS

Thirteen cycloartane triterpenoids were isolated from the rhizomes of C. foetida and were characterized as 25-O-acetyl-cimigenol (1), cimigenol (2), cimicidanol (3), 26-deoxyactein (4), asiaticoside A (5), 23-epi-26-deoxyactein (6), actein (7), 12beta-hydroxycimigenol (8), cimiside E (9), (23R, 24S) 25-O-acetyl-cimigenol-3-O-beta-D-xylopyranoside (10), (23R, 24S) cimigenol-3-O-beta-D-xylopyranoside (11), cimicifugoside H-1 (12) and cimicifugoside H-2 (13).

CONCLUSIONS

Compound 5 was isolated from this genus for the first time, compound 7 was isolated firstly from the plant and compound 2, 7, 10 and 11 exhibit osteoclast inhibition activity.