Dexmedetomidine. Dexmedetomidine use 400 mcg in 100 cc 0.9% physiological solution in continuous infusion starting at a dose of 0.2 mcg / kg / hr titrating until reaching a decrease in the adrenergic response, with a maximum dose of 0.7 mcg / kg / hr7.
Dosage form: DEX 0.2-0.7 mcg/Kg/min.

Dosage form: Diazepam 5-10 mg IV, steps until a maximum dose of 120 mg diazepam

Alcohol Withdrawal Delirium

Experimental studies and single case reports suggest the α2-agonist dexmedetomidine is effective in managing the autonomic symptoms seen with alcohol withdrawal.

Dexmedetomidine 0.004 MG/ML

diazepam start with 5-20 mg IV as a dose response, steps until a maximum dose of 120 mg diazepam.

Diazepam Injectable Solution

Nayely Garcia Mendez

Treatment Of Alcohol Withdrawal Syndrome: Dexmedetomidine Vs Diazepam In A Hospital O'horán

Total Score = 0 - 9: absent or minimal withdrawal 10 - 19: mild to moderate withdrawal more than 20: severe withdrawal

mean values per 24 hours period for each patient

GARCIA MENDEZ NAYELY

Post doc Medical Sciences, Visiting professor, Universidad de la Frontera.

Centro Medico Nacional La Raza, IMSS

Universidad de la Frontera

Clinical Trials To compare Diazepam 5-20 mg IV or Dexmedetomidine 0.2-0.7 mcg / Kg / min., In monotherapy until the CIWA-Ar decreases to <10.

29 women randomized to Belladonna & Opium suppository

27 women randomized to Glycerin suppository

29 women randomized to Belladonna & Opium suppository
Belladonna Opium: Belladonna Opium 16.2-60mg rectal suppository

Belladonna & Opium

27 women randomized to Glycerin suppository
Glycerin Suppository: Glycerine rectal suppository

Placebo

Total

Sex: Female, Male

Race and Ethnicity Not Collected

Pre-operative diagnosis of pelvic pain, dysmenorrhea, or dyspareunia

Pain-related indication for surgery

Robotic surgery

Laparoscopic surgery

Performed by a high-volume surgeon

Surgery length

Planned admission for 23-hour observation

Dexamethasone while under anesthesia

Lidocaine while under anesthesia

Ketorolac while under anesthesia

Zofran while under anesthesia

Reglan while under anesthesia

Scopolamine patch pre-operatively

Visual analog pain scale (VAS) (0 to 10, 0 = no pain, 10 = maximum pain), averaged over duration of PACU stay until discharge criteria met

Post-operative Pain: VAS

Cumulative oral and intravenous narcotics received in PACU until PACU discharge criteria met

Narcotic Use

Time elapsed from conclusion of surgery until criteria for PACU discharge met

Time Until Cleared for PACU Discharge

Binary assessment of whether anti-emetics received in PACU

Number of Participants for Which Anti-emetics Were Received in PACU

Overall Study

Anna Reinert, MD

Hysterectomy

Pain, Postoperative

Belladonna Opium 16.2-60mg rectal suppository

Belladonna Opium

Glycerin Suppository

Mercy Medical Center

B&O for TLH Post-operative Pain and Nausea

Belladonna and Opium Rectal Suppository Effect on Postoperative Pain and Nausea Following Total Laparoscopic and Robotic-Assisted Hysterectomy

Anna Reinert

Study coordinator, Resident Physician

University of Maryland, College Park

Randomization to one-time intervention A (medicated suppository) or intervention B (placebo), allocation was sealed in consecutively numbered opaque envelopes generated by biostatistician using blocked randomized technique.

Opaque sealed envelopes generated by biostatistician used to determine intervention A or B. Drug dictionary entries created within the Pyxis system by the Mercy Medical Center Department of Pharmacy, as "Protocol Drug A" and "Protocol Drug B", recorded in medical record in this way. Identity of "Protocol Drug A" and "Protocol Drug B" revealed by pharmacist at conclusion of data analysis.

alcohol withdrawal delirium/nausea

Treatment Of Alcohol Withdrawal Syndrome: Dexmedetomidine Vs Diazepam In A Hospital O'horán

B&O for TLH Post-operative Pain and Nausea

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