A longitudinal study of one cohort of 360 participants aged at least 60 years. Participants will be required to provide a stool sample, provide a blood sample and complete a health questionnaire every 6 months for 4 years. At alternate visits, participants will be required to under go cognitive assessments and physical measurements.
Participants will be required to under go an Optical Coherence Tomography Scan 3 times over 4 years.
Sub group 1 - During a routine care colonoscopy, at least 90 participants will have 6-8 colon tissue biopsies taken for research purposes.
Sub group 2 - Participants from cohort 3 only will be offered an optional brain MRI until the required number of 30 participants is achieved.

Ageing

Quadram Institute Bioscience

Microbiome of the Ageing Gut and Its Effect on Human Gut Health and Cognition.

A Longitudinal Study in a Cohort Aged 60 Years and Older to Obtain Mechanistic Knowledge of the Role of the Gut Microbiome During Normal Healthy Ageing in Order to Develop Strategies That Will Improve Lifelong Health and Wellbeing.

Changes in microbiome measured by DNA/RNA sequencing of longitudinal samples collected at 6 monthly intervals.

Banking of longitudinal samples collected throughout the study that will be used in future research.

Changes in microbial composition associated with cognitive function and clinical data collected throughout the study.

The study team will ensure fully compliance with the standards required for deposition of information in any relevant public databases. Anonymised datasets will be kept indefinitely and available to other researchers to comply with journal requirements when required.

Norfolk and Norwich University Hospitals NHS Foundation Trust

Placebo suppository; once daily for 7 days.

DHEA 0.50% (6.5 mg) suppository; once daily for 7 days.

DHEA 1.0% (13 mg) suppository; once daily for 7 days.

DHEA 1.8% (23.4 mg) suppository; once daily for 7 days.

Vaginal Atrophy

DHEA

Placebo

Clinique des traitements hormonaux CHUL Research Center

DHEA Bioavailability Following Administration of Vaginal Suppositories in Post-Menopausal Women With Vaginal Atrophy

DHEA Bioavailability Following Administration of Vaginal Suppositories in Post-Menopausal Women With Vaginal Atrophy-Phase I Randomized,Placebo-Controlled, Double-Blind Study.

atrophic vaginitis/murtall

Microbiome of the Ageing Gut and Its Effect on Human Gut Health and Cognition.

DHEA Bioavailability Following Administration of Vaginal Suppositories in Post-Menopausal Women With Vaginal Atrophy

An bunachar luibheanna míochaine is iomláine le tacaíocht ón eolaíocht