Cigarette smoking and alcohol consumption possibly affect platelet functions. To verify the hypothesis that some α-, β-, and γ-carboline components in cigarette smoke and alcoholic beverages may change platelet aggregability, their effects on human platelets were determined by aggregometry together
The in vitro conversion of (1S,3S)-1-dimethoxylethyl-1,2,3,4-tetrahydro- β-carboline-3-carboxylic acid, (1S,3S)-DCCA, in rat plasma is monitored by HPLC- FT-ICR-MS. We show that the in vitro conversion of (1S,3S)-DCCA in rat plasma for 1 h leads to forming (6S/12aS)-bisdimethoxyethylheptachpyridone,