dehydroascorbic acid/athlasadh

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The contribution of ascorbic acid and dehydroascorbic acid to the protective role of pleura during inflammatory reactions.

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Logáil Isteach / Cláraigh

It is well-known that parapneumonic effusions lead to the formation of inflammatory exudates which contain an increasing amount of inflammatory cells, especially polymorphonuclear. At these pathological conditions characterized by oxidative stress, ascorbic acid (AA) plays an important role in

Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat.

Ní féidir ach le húsáideoirí cláraithe ailt a aistriú

Logáil Isteach / Cláraigh

We investigated the effect of dehydroascorbic acid (DHA), the oxidized form of vitamin C which is a superoxide scavenger, on manganese superoxide dismutase (MnSOD), copper-zinc SOD (CuZnSOD), cyclooxygenase-2 (COX-2) and interleukin-1beta (IL-1beta) expression in a rat model of focal cerebral

[Studies of complicated cataract. VII. Equilibrium between ascorbic acid and dehydroascorbic acid in ocular tissues and liquids in normal persons and during the inflammation of the uvea].

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Logáil Isteach / Cláraigh

Storage-induced increase in biomarkers of oxidative stress and inflammation in red blood cell components.

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Logáil Isteach / Cláraigh

BACKGROUND Transfusion of blood components may increase the risk of complications in relation to surgery. During storage, red blood cells (RBCs) undergo structural and functional changes that may reduce function and viability after transfusion. The aim of the study was to evaluate the quality of

Sepsis inhibits reduction of dehydroascorbic acid and accumulation of ascorbate in astroglial cultures: intracellular ascorbate depletion increases nitric oxide synthase induction and glutamate uptake inhibition.

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Logáil Isteach / Cláraigh

Sepsis is associated with oxidative stress and impaired glutamatergic transmission in brain. We investigated whether sepsis impairs accumulation of the antioxidant, ascorbate, and uptake of glutamate by astrocytes. Bacterial endotoxin (Escherichia coli lipopolysaccharide, LPS) and the inflammatory

Dehydroascorbic Acid, the Oxidized Form of Vitamin C, Improves Renal Histology and Function in Old Mice

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Logáil Isteach / Cláraigh

Oxidative stress and inflammation are crucial factors that increase with age. In the progression of multiple age-related diseases, antioxidants and bioactive compounds have been recognized as useful antiaging agents. Oxidized or reduced vitamin C exerts different actions on tissues and has different

Altered ascorbic acid status in the mucosa from inflammatory bowel disease patients.

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Logáil Isteach / Cláraigh

Attempts to establish the presence of oxidant stress and tissue damage in inflammatory bowel disease (IBD) have relied on determining the capacity of peripheral blood inflammatory cells to produce reactive oxygen species (ROS) and other indirect indices. These approaches have failed to address

The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease.

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Logáil Isteach / Cláraigh

Background: Variations in intestinal antioxidant membrane transporters are implicated in the initiation and progression of inflammatory bowel disease (IBD). Facilitated glucose transporter member 14 (GLUT14), encoded by the solute carrier family 2 member 14 (SLC2A14) gene, is a putative transporter

Ascorbic acid levels in aqueous and vitreous humors of the rabbit: effects of inflammation and ceruloplasmin.

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Logáil Isteach / Cláraigh

A HPLC method for determination of ascorbic acid and dehydroascorbic acid in plasma and aqueous and vitreous humors of rabbits is described. Values for total ascorbic acid concentration found in this study are in agreement with those of previous investigators. Endotoxin-induced ocular inflammation

A novel biological role of dehydroascorbic acid: Inhibition of Na(+)-dependent transport of ascorbic acid.

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Logáil Isteach / Cláraigh

A U937 cell clone, in which low micromolar concentrations of ascorbic acid (AA) and dehydroascorbic acid (DHA) are taken up at identical rates, was used to investigate possible interactions between transport systems mediating cellular uptake of the two forms of the vitamin. Results obtained with

Micronutrient concentrations in patients with malignant disease: effect of the inflammatory response.

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Logáil Isteach / Cláraigh

BACKGROUND Micronutrient deficiencies may occur in patients with malignancy due to a variety of possible causes, including unbalanced dietary intake and adverse effects of treatment. In addition, many patients show signs of a chronic inflammatory response, which can affect circulating concentrations

Pronounced inflammatory response to endotoxaemia during nighttime: a randomised cross-over trial.

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Logáil Isteach / Cláraigh

BACKGROUND Circadian variation in bodily functions has been shown to impact health in acute and chronic medical conditions. Little is known about the relationship between circadian rhythm and sepsis in humans. We aimed to investigate circadian variations in the host response in a human endotoxaemia

Dehydroascorbic acid and oxidative stress in haemodialysis patients.

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Logáil Isteach / Cláraigh

BACKGROUND The amount of dehydroascorbic acid contained within total ascorbic acid (oxidized as well as non-oxidized forms) in plasma, hereafter referred to as the dehydroascorbic acid fraction, may be a measure of oxidative stress during haemodialysis. In the present study, we determined this

Lower limb ischaemia and reperfusion injury in healthy volunteers measured by oxidative and inflammatory biomarkers.

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Logáil Isteach / Cláraigh

OBJECTIVE Ischaemia-reperfusion (IR) injury is partly caused by the release of reactive oxygen species and cytokines and may result in remote organ injury. Surgical patients are exposed to surgical stress and anaesthesia, both of which can influence the IR response. An IR model without these

Melatonin suppresses markers of inflammation and oxidative damage in a human daytime endotoxemia model.

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Logáil Isteach / Cláraigh

OBJECTIVE Melatonin used as an exogenous drug has been documented to have potent antioxidant and anti-inflammatory effects in animal model. We aimed to examine the effect of melatonin in an experimental human sepsis model. METHODS Twelve healthy males were enrolled in a randomized,

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