16 patients to receive 1 homologated placebo capsule (calcinated magnesia 500 mg) every 12 hours along 12 weeks

16 patients to receive 1 homologated intervention capsule (ellagic acid 500 mg) every 12 hours along 12 weeks

Metabolic Syndrome

Phenolic acid, ellagitannin, found in a wide variety of fruits and nuts; in this particular case, pomegranate extract with ellagic acid 90% 500mg capsules. Homologated to the other intervention. Dosage twice a day orally every 12 hours during 12 weeks

Ellagic Acid / Pomegranate Extract

Calcinated magnesia in 500mg capsules. Homologated to the other intervention. Dosage twice a day orally every 12 hours during 12 weeks

Placebo oral capsule

INSTITUTO DE TERAPÉUTICA EXPERIMENTAL Y CLÍNICA. Centro Universitario de Ciencias de la Salud

Effect of Ellagic Ácid on the Components of Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion

Effect of Ellagic Acid Administration on the Components of Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion

Main criteria for metabolic syndrome diagnosis

systolic blood pressure and diastolyc blood pressure by digital blood pressure monitor

fasting blood glucose by enzimatic-colorimetric automatized technique

fasting blood triglycerides by enzimatic-colorimetric automatized technique

fasting blood high density lypoprotein-cholesterol by enzimatic-colorimetric automatized technique

From an oral glucose tolerance test with glucose 75g intake, and each 30 minutes sampling to get insulin and glucose levels; minuted glucose and insulin results will be analized with Matsuda Index to get insulin sensitivity

Stumvoll and insulinogenic indexes will be used to calculating first-phase and total insulin secretion

body weight measured by bioelectrical impedance scale

body mass index (BMI) will be calculated with the Quetelet index formula

body fat will be estimated by bioelectrical impedance analysis

fasting blood total cholesterol by enzimatic-colorimetric automatized technique

fasting blood low-density lipoprotein- cholesterol by enzimatic-colorimetric automatized technique

fasting blood very low-density lipoprotein by enzimatic-colorimetric automatized technique

aminotransferases by enzimatic-colorimetric automatized technique

fasting blood uric acid by enzimatic-colorimetric automatized technique

creatinine by enzimatic-colorimetric automatized technique

Incidence of placebo or ellagic acid, emergent adverse events will be identified by clinical evaluation

Karina Griselda Pérez Rubio

Principal Investigator

University of Guadalajara

National Council of Science and Technology, Mexico

Double-blind, placebo-controlled clinical trial

50g of flavonoid-rich freeze-dried strawberry powder

50g macronutrient-matched control powder that will lack strawberry flavonoids

Childhood Obesity

Cardiovascular Disease

flavonoid-rich freeze-dried strawberry powder

50g macronutrient-matched powder that will lack strawberry flavonoids

macronutrient-matched control powder

Ragle Human Nutrition Research Center, Academic Surge, UC Davis

The Effects of California Strawberries on Parameters of Cardiovascular Health

Change from baseline at 1 hour and 1 week post consumption of freeze-dried strawberry powder or control powder

University of California, Davis

Rhinitis

Sinusitis

Nasal Polyps

Hillel Yaffe Medical Center

The Clinical Efficacy of Topical Nasal Pomegranate Fruit Extract for Patients With Chronic Rhinosinusitis

The Clinical Efficacy of Topical Nasal Pomegranate Fruit Extract (PFE) for Patients With Chronic Rhinitis, Chronic Sinusitis With or Without Nasal Polyps

ellagic acid/murtall

Effect of Ellagic Ácid on the Components of Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion

The Effects of California Strawberries on Parameters of Cardiovascular Health

The Clinical Efficacy of Topical Nasal Pomegranate Fruit Extract for Patients With Chronic Rhinosinusitis

An bunachar luibheanna míochaine is iomláine le tacaíocht ón eolaíocht