Participants with history of a head injury and confirmed PNES will complete 2 brain fMRI scans along with 12 weeks of one hour CBT-Sz sessions by a trained therapist.

Participants with history of a head injury and confirmed post-traumatic epilepsy (PTE) will complete 2 brain fMRI scans along with 12 weeks of one hour CBT-Sz sessions by a trained therapist.

Participants with TBI will complete 2 brain fMRI scans.

Seizure Disorder

Seizure Disorder, Post Traumatic

Traumatic Brain Injury

Non-Epileptic Seizure

Conversion Disorder

Magnetic Resonance Imaging

CBT-informed psychotherapy for patients with PNES and PTE

Cognitive Behavioral Therapy for Seizures

Standard Medical Care

University of Alabama at Birmingham

Rhode Island Hospital

Providence VA Medical Center

Neuroimaging Biomarker for Seizures

epileptic seizure frequency (ES), collected prospectively, using a daily seizure calendar

psychogenic nonepileptic seizure (NES) frequency, collected prospectively, using a daily seizure calendar

The BDI-II assesses depression severity from "0" (no Depression-related symptom) to "3" (severe) on each question. The highest possible score is "51", relating to the worst outcome.

The BDI-II assesses anxiety severity from "0" (no Anxiety-related symptom) to "3" (severe) on each question.

his is a 31-item self-report scale used in the seizure population to evaluate Quality of Life. The lowest possible score is 0 and the highest possible score is 100, reflecting a better quality of life.

Birmingham, Alabama VA Medical Center

United States Department of Defense

Ocean State Research Institute, Inc.

Brown University

The neuroimaging analysis will be masked.

Head Trauma

Pediatric Emergency Department - Necker-Enfants malades Hospital -

Infant Minor Head Trauma Clinical Decision Rule

Performance of a Minor Head Trauma Clinical Decision Rule Dedicated to Children Younger Than Two Years: A National Prospective Multicenter Study

Clinically-important traumatic brain injury defined by: death, intubation > 24h, neurosurgical intervention and/or admission > 2 nights for head injury with traumatic brain injury on CT scan

Assessment of the number of children with any of the PELICAN predictive variables recommending CT scan ordering

Performance of the age-based PECARN TBI prediction rule for identifying ciTBI

to analyse the different management care strategies applied to a large national French observational study population

Presence of a TBI on CT scan that doesn't result in death, intubation < 24h, neurosurgery and/or admission over 2 nights, in a patient who had no PELICAN predictors recommending CT scan.
Presence in these patients of post-traumatic signs or symptoms requiring admission or any specific therapy

Presence of a PELICAN variable recommending short clinical observation

Assistance Publique - Hôpitaux de Paris

Francophone Pediatric Resuscitation and Emergency Group (GFRUP)

Epilepsy, Post-Traumatic

1500 mg/day orally until the first episode of late epilepsy for a maximum duration of 3 months

Levetiracetam

Placebo

Neurologie - CHU Angers

Neurology - CHU Bordeaux

Neurologie - CHU Caen

Neurochirurgie-CHU Grenoble

Neurology - CHU Rennes

Neurophysiologie Clinique - CHU Lille

Neurophysiologie clinique - CHU Lyon (Hôpital neurologique)

Beurophysiologie clinique - CHU Marseille

Epileptologie - CHU Montpellier

Neurologie - CHU Nancy

Neurochirurgie-Paris Saint Anne

Neurologie - CHU Rennes

Explorations Fonctionnelles Neurologiques - CHU Nantes

Neurologie - CHU Rouen

Neurologie - CHU Tours Hopital Trousseau

Prevention of Post-traumatic Seizures With Levetiracetam

Prospective, Randomized, Double-blind Study Assessing the Effects of Levetiracetam Compared to Placebo in the Prevention of Early Epileptic Seizures and Late Epilepsy in Patients With Severe Traumatic Brain Injury

epilepsy post-traumatic/seizures

Neuroimaging Biomarker for Seizures

Infant Minor Head Trauma Clinical Decision Rule

Prevention of Post-traumatic Seizures With Levetiracetam

Characteristics of Blood- Brain Barrier Permeability in Neurological Patients

An bunachar luibheanna míochaine is iomláine le tacaíocht ón eolaíocht