The Combined group patients received Argon plasma coagulation therapy, PSD-60/Endoplasma (Olympus Corporation, Tokyo, Japan), following distilled water injection at index endoscopy. Then participants were treated with intravenous pantoprazole (Pantoloc i.v., Nycomed GmbH, Singen, Germany) 40 mg every 12 hours during the first 3 days, followed by oral pantoprazole (Pantoloc, Takeda GmbH, Oranienburg, Germany) 40 mg daily until the end of 56-day study period.

Injection group patients underwent distilled water alone at index endoscopy. Then patients were treated with intravenous pantoprazole (Pantoloc i.v., Nycomed GmbH, Singen, Germany) 40 mg every 12 hours during the first 3 days, followed by oral pantoprazole (Pantoloc, Takeda GmbH, Oranienburg, Germany) 40 mg daily until the end of 56-day study period.

Bleeding Ulcers

Argon plasma coagulation therapy was realized by an Olympus electrosurgical unit/APC unit (PSD-60/Endoplasma, Olympus Corporation, Tokyo, Japan), and its catheters were 2.3mm and 3.5 mm equipped with different endoscope channels.7 APC treatment used a coagulation mode at gas flow/power settings of 1.5L/min and 40 watt for duodenal ulcers and 40-60 watt for gastric ulcers.10 Operative distance between the probe and target bleeding ranged from 2 to 8 mm. Air warranted to be sucked frequently at endoscopy in an attempt at decrease of APC-induced smoke and gastric decompensation, with appropriate treatment of high-risk bleeding ulcers.

Argon plasma coagulation

Distilled water was then applied in aliquots of 0.5-2.0 mL, at and around the site of target bleeding, up to 25.0 ml if necessary. Injection amount was determined by endoscopists according to ulcer or vessel size and its location.

Distilled water

Division of Gastroenterology, Department of Internal Medicine

Argon Plasma Coagulation for Bleeding Peptic Ulcers

Ivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

Rebleeding was observed for a 30-day study period. One or more the following criteria were considered as evidence of recurrent bleeding: aspiration of fresh blood from a nasogastric or orogastric tube; pulse rate over 100 beats per minute; a drop in systolic blood pressure exceeding 30 mmHg; or continue coffee ground emesis or melena with a decline in hemoglobin of at least 2g/dL.

Namely, stricture, obstruction and perforation

Huay-Min Wang

Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung,Taiwan

Kaohsiung Veterans General Hospital.

Patients randomized to medical therapy received optimized treatment with PPI using a standardized management protocol based on best evidence and published guidelines.

Surgical patients underwent LNF using previously published technique.

Gastroesophageal Reflux

Proton Pump Inhibitors

Laparoscopic Nissen Fundoplication

St. Joseph's Healthcare Hamilton

A Randomized Controlled Trial of Laparoscopic Nissen Fundoplication Treatment of Patients With Chronic GERD

ELVIS (Esophagitis-Laparoscopy Versus Inhibitors of Secretion) A Randomized Controlled Trial of Laparoscopic Nissen Fundoplication (LNF) Versus Omeprazole for Treatment of Patients With Chronic Gastro-Esophageal Reflux Disease (GERD)

Mehran Anvari

Principal Investigator

McMaster University

Radiation therapy and chemotherapy + Amifostine

Drug/Agent Toxicity by Tissue/Organ

Lung Cancer

Oral Complications

Radiation Toxicity

filgrastim

amifostine trihydrate

carboplatin

paclitaxel

radiation therapy

University of Alabama at Birmingham Comprehensive Cancer Center

Huntsville Hospital System

Comprehensive Cancer Institute of Huntsville

MBCCOP - Gulf Coast

Alabama Oncology, LLC

Radiation Oncology Associates of West Alabama

Providence Alaska Medical Center

Foundation for Cancer Research and Education

Arizona Cancer Center

University of Arkansas for Medical Sciences

Mount Diablo Medical Center

Cancer Center and Beckman Research Institute, City of Hope

California Cancer Center

Saint Agnes Cancer Center

Glendale Memorial Hospital and Health Center

Sutter Health West Cancer Research Group

University of California San Diego Cancer Center

Loma Linda University Medical Center

Veterans Affairs Medical Center - Long Beach

USC/Norris Comprehensive Cancer Center and Hospital

Jonsson Comprehensive Cancer Center, UCLA

CCOP - Bay Area Tumor Institute

Huntington Cancer Center

Cancer Care Center

Radiation Oncology Center - Sacramento

Radiation Medical Group, Inc.

UCSF Cancer Center and Cancer Research Institute

O'Connor Hospital

CCOP - Santa Rosa Memorial Hospital

David Grant Medical Center

Memorial Hospital Cancer Center

University of Colorado Cancer Center

Saint Mary's Hospital and Medical Center

CCOP - Christiana Care Health Services

Walter Reed Army Medical Center

Lykes Center for Radiation Therapy

Halifax Medical Center

Radiation Therapy Associates - Fort Myers

University of Florida Health Science Center

Health First Holmes Regional Medical Center

CCOP - Mount Sinai Medical Center

Veterans Affairs Medical Center - Miami

Sylvester Cancer Center, University of Miami

Baptist Hospital of Miami

Florida Radiation Oncology Group

MD Anderson Cancer Center Orlando

Bay Medical Center

Gulf Coast Cancer Treatment Center

Sarasota Radiation and Medical Oncology Center

Tallahassee Memorial Healthcare

H. Lee Moffitt Cancer Center and Research Institute

Emory University Hospital - Atlanta

CCOP - Atlanta Regional

Medical Center/John B. Amos Community Cancer Center

Regional Radiation Oncology Center at Rome

MBCCOP - Hawaii

Northwest Community Hospital

Northwestern Memorial Hospital

University of Chicago Cancer Research Center

CCOP - Central Illinois

Provena St. Joseph Hospital- Regional Cancer Care Center

Ingalls Memorial Hospital

Loyola University Medical Center

Lutheran General Cancer Care Center

Methodist Medical Center of Illinois

St. John's Medical Center

Bloomington Hospital

Veterans Affairs Medical Center - Indianapolis (Roudebush)

Clarion Health Partners Inc.

Community Hospitals of Indianapolis - Regional Cancer Center

Ball Memorial Hospital

CCOP - Northern Indiana CR Consortium

Wendt Regional Cancer Center of Finley Hospital

Holden Comprehensive Cancer Center at The University of Iowa

Central Baptist Hospital

Veterans Affairs Medical Center - Lexington

Albert B. Chandler Medical Center, University of Kentucky

James Graham Brown Cancer Center

Louisville Radiation Oncology

Merle M. Mahr Cancer Center

Mary Bird Perkins Cancer Center

Romagosa Radiation Oncology Center

MBCCOP - LSU Health Sciences Center

Tulane University School of Medicine

CCOP - Ochsner

Maine Medical Center

Anne Arundel Oncology Center

Greater Baltimore Medical Center and Cancer Center

Harbor Hospital Center

Sinai Hospital of Baltimore

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Radiation Oncology Affiliates of Maryland, P.A.

Peninsula Regional Medical Center

Cape Cod Hospital

Veterans Affairs Medical Center - Boston (Jamaica Plain)

CCOP - Ann Arbor Regional

University of Michigan Comprehensive Cancer Center

Barbara Ann Karmanos Cancer Institute

Henry Ford Hospital

McLaren Regional Cancer Center

Amifostine in Treating Patients With Stage II or Stage III Non-small Cell Lung Cancer

A Phase III Randomized Study of Amifostine Mucosal Protection for Patients With Favorable Performance Inoperable Stage II-III A/B Non-Small Cell Lung Cancer (NSCLC) Receiving Sequential Induction and Concurrent Hyperfractionated Radiotherapy With Paclitaxel and Carboplatin

esophagitis/nicitín

Argon Plasma Coagulation for Bleeding Peptic Ulcers

A Randomized Controlled Trial of Laparoscopic Nissen Fundoplication Treatment of Patients With Chronic GERD

Amifostine in Treating Patients With Stage II or Stage III Non-small Cell Lung Cancer

An bunachar luibheanna míochaine is iomláine le tacaíocht ón eolaíocht