nevus/protease

Sábháiltear an nasc chuig an gearrthaisce

AiltTrialacha cliniciúlaPaitinní

Roghnaigh cineál sórtála

5 torthaí

Extraction of a melanoma growth-stimulatory activity from culture medium conditioned by the Hs0294 human melanoma cell line.

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Logáil Isteach / Cláraigh

Extracts of conditioned medium (CM) from Hs0294 human malignant melanoma cells stimulate [3H]thymidine incorporation and an increase in cell number in serum-depleted Hs0294 cells. This activity is acid and heat stable, nonproteolytic, protease sensitive, contains disulfide bonds and elutes broadly

Activity, expression, and transcription rate of the cathepsins B, D, H, and L in cutaneous malignant melanoma.

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Logáil Isteach / Cláraigh

BACKGROUND Increased activity of the protease cathepsin B has been demonstrated in many tumor cells. A correlation of cathepsin B activity and metastatic potential of melanoma has been well established. METHODS The cathepsins B, D, H, and L were evaluated in normal skin, nevi, and melanoma samples

Keratinocytes drive melanoma invasion in a reconstructed skin model.

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Logáil Isteach / Cláraigh

Melanoma progression is a multistep progression from a common melanocytic nevus through the radial growth phase, the invasive vertical growth phase finally leading to metastatic spread into distant organs. Migration and invasion of tumor cells requires secretion of proteases to facilitate remodeling

[Angiogenesis and tumor progression in melanoma].

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Logáil Isteach / Cláraigh

Angiogenesis is defined as the formation of new blood capillaries from preexisting vessels. It takes place in physiological and pathological conditions, such as cancer. Tumor angiogenesis depends on the release of angiogenic growth factors by tumor cells and infiltrating inflammatory cells, and from

Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma.

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Logáil Isteach / Cláraigh

The spliceosome machinery composed of multimeric protein complexes guides precursor messenger RNAs (mRNAs) (pre-mRNAs) splicing in eukaryotic cells. Spliceosome components have been shown to be downregulated in cancer and could be a promising molecular target for anticancer therapy. The

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Herbal & Natural Medicine

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