palmitoleic acid/murtall

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Maternal obesity results in decreased syncytiotrophoblast synthesis of palmitoleic acid, a fatty acid with anti-inflammatory and insulin-sensitizing properties.

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Logáil Isteach / Cláraigh

The fetus is dependent on delivery of fatty acids (FAs) by the syncytiotrophoblast, the transporting epithelium of the human placenta. Obese pregnant women have dyslipidemia; however, whether obesity impacts placental lipid transport and metabolism remains to be fully established. Palmitoleic acid

Increased plasma levels of palmitoleic acid may contribute to beneficial effects of Krill oil on glucose homeostasis in dietary obese mice.

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Logáil Isteach / Cláraigh

Omega-3 polyunsatuarted fatty acids (PUFA) are associated with hypolipidemic and anti-inflammatory effects. However, omega-3 PUFA, usually administered as triacylglycerols or ethyl esters, could also compromise glucose metabolism, especially in obese type 2 diabetics. Phospholipids represent an

Palmitoleic acid reduces intramuscular lipid and restores insulin sensitivity in obese sheep.

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Logáil Isteach / Cláraigh

Obese sheep were used to assess the effects of palmitoleic (C16:1 cis-9) acid infusion on lipogenesis and circulating insulin levels. Infusion of 10 mg/kg body weight (BW)/day C16:1 intravenously in obese sheep reduced (P<0.01) weight gain by 77%. Serum palmitoleic levels increased (P<0.05) in a

Plasma palmitoleic acid content and obesity in children.

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Logáil Isteach / Cláraigh

BACKGROUND Palmitoleic acid (16:1n-7) is a product of endogenous lipogenesis. In human obesity, 16:1n-7 is reported to correlate with indexes of adiposity and insulin concentrations. OBJECTIVE We investigated the relation between adiposity, especially in the abdominal region, and plasma

Adipose tissue palmitoleic acid and obesity in humans: does it behave as a lipokine?

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Logáil Isteach / Cláraigh

BACKGROUND Animal models have shown that adipose-derived palmitoleic acid may serve as a lipokine that contributes to resistance to diet-induced obesity. Studies in humans have evaluated only plasma palmitoleic acid concentrations, which reflect stearoyl-coenzyme A desaturase 1 (SCD1) activity in

Genetic obesity alters recruitment of TANK-binding kinase 1 and AKT into hypothalamic lipid rafts domains.

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Logáil Isteach / Cláraigh

Lipid rafts (LRs) are membrane subdomains enriched in cholesterol, glycosphingolipids and sphingolipids containing saturated fatty acid. Signaling proteins become concentrated in these microdomains mainly by saturated fatty acid modification, thus facilitating formation of protein complexes and

Depot-specific differences in fatty acid composition and distinct associations with lipogenic gene expression in abdominal adipose tissue of obese women.

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Logáil Isteach / Cláraigh

Cardiometabolic diseases are primarily linked to enlarged visceral adipose tissue (VAT). However, some data suggest heterogeneity within the subcutaneous adipose tissue (SAT) depot with potential metabolic differences between the superficial SAT (sSAT) and deep SAT (dSAT) compartments. We aimed to

The use of the adipose tissue transplantation technique to demonstrate that abnormalities in the adipose tissue metabolism of genetically obese mice are due to extrinsic rather than intrinsic factors.

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Logáil Isteach / Cláraigh

Adipose tissue transplantation between genetically obese mice and their lean counterparts using the kidney capsule as the transplantation site has shown that the abnormally large fat cells of obese mice normalize in size when they are placed into a 'lean' environment. Furthermore, the abnormal fatty

Changes in individual plasma free fatty acids in obese females during fasting and refeeding.

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Logáil Isteach / Cláraigh

In order to determine whether the metabolism of individual free fatty acids is affected by fasting, plasma levels were measured daily in seven obese females during ten days of fasting and four days of refeeding. There was a gradual rise in free fatty acids throughout the fasting period with some

Up-regulation of stearoyl-CoA desaturase 1 increases liver MUFA content in obese Zucker but not Goto-Kakizaki rats.

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Logáil Isteach / Cláraigh

The Goto-Kakizaki (GK) rat is an animal model for spontaneous-onset, non-obese type 2 diabetes. Despite abundant evidence about disorders in metabolism, little information is available about fatty acid metabolism in the liver of GK rats. This study aimed to investigate the characteristics of the

Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes.

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Logáil Isteach / Cláraigh

BACKGROUND Studies have demonstrated the beneficial effect of palmitoleic acid (C16:1 n-7) on reducing muscle insulin resistance and preventing beta-cell apoptosis. However, the effect of palmitoleic acid on diabetes remains to be elucidated. The aim of this study was to examine the antidiabetic

Plasma lipidomic signatures of spontaneous obese rhesus monkeys.

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Logáil Isteach / Cláraigh

Obesity plays crucial roles in the pathogenesis of metabolic diseases such as hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), and type 2 diabetes (T2D). The underlying mechanisms linking obesity to metabolic diseases are still less

Effects of two-months balanced diet in metabolically healthy obesity: lipid correlations with gender and BMI-related differences.

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Logáil Isteach / Cláraigh

BACKGROUND Nowadays no researches has been performed on fatty acid profile (FA) and desaturase activity in metabolically healthy obesity (MHO). The aim of this study was to assessed gender and BMI-related difference in FA, estimated desaturase activities and the efficacy on metabolic changes

Obesity-related metabolite profiles of black women spanning the epidemiologic transition.

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Logáil Isteach / Cláraigh

In developed countries, specific metabolites have been associated with obesity and metabolic diseases, e.g. type 2 diabetes. It is unknown whether a similar profile persists across populations of African-origin, at increased risk for obesity and related diseases. In a cross-sectional study of

Relation between degree of obesity and site-specific adipose tissue fatty acid composition in a Mediterranean population.

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Logáil Isteach / Cláraigh

OBJECTIVE Obesity itself could be a key factor determining fatty acid (FA) composition of adipose tissue (AT). A Mediterranean diet influences this relationship. However, a relation between different overweight and obesity levels (including morbidly obese subjects) and AT FA pattern has not been

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