60 day oral administration of sugar placebo twice per day before lunch and supper.

60 day oral administration of active study drug (methylphenidate) twice per day before lunch and supper.

Obesity

60 days on oral methylphenidate administered 2 times daily before lunch and supper.

60 days on oral placebo administered 2 times daily before lunch and supper

Placebo

Children's Hospital Of Eastern Ontario Research Institute

University of Ottawa

The Effects of Methylphenidate on Energy Intake and Energy Expenditure

The Effects of Methylphenidate on the Reduction of Food Energy Intake and on the Augmentation of Energy Expenditure

Participant will be offered a lunch buffet that includes items they indicate are preferred. They will be able to eat as much or as little as they choose.

Indirect calorimetry measure: participant lies supine on a bed while a neoprene mask is attached to their face. Expired breath is captured by the metabolic cart to assess resting energy expenditure and the thermic effect of feeding.

Participant stands next to a stadiometer; height will be used to determine BMI at baseline.

This measure is a conglomerate of body weight (kg) divided by height (meters squared)

A "go/no-go"computer task that measures reaction time to food and non-food cues with simple button-presses on a keyboard.

Odourized pens, called Sniffin Sticks, are used to measure odour detection threshold for a non-toxic odourant called n-butanol.

We have not made a plan to make IPD available. We do plan on publishing the findings, but as per normal scientific reporting, with deidentified data.

piperidine/nausea

The Effects of Methylphenidate on Energy Intake and Energy Expenditure

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