propionic acid/cannabas

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AiltTrialacha cliniciúlaPaitinní

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5 torthaí

Presynaptic mechanisms underlying cannabinoid inhibition of excitatory synaptic transmission in rat striatal neurons.

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Logáil Isteach / Cláraigh

The striatum is a crucial site of action for the motor effects of cannabinoids (CBs). However, the electrophysiological consequences of activation of CB receptors on the striatal neurons have not been established. Here we report for the first time that the cannabimimetic aminoalkylindole WIN

Possible mechanisms of cannabinoid-induced antinociception in the spinal cord.

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Logáil Isteach / Cláraigh

Anandamide is an endogenous ligand at both the inhibitory cannabinoid CB(1) receptor and the excitatory vanilloid receptor 1 (VR1). The CB(1) receptor and vanilloid VR1 receptor are expressed in about 50% and 40% of dorsal root ganglion neurons, respectively. While all vanilloid VR1

Human phase I metabolism of the novel synthetic cannabinoid 5F-CUMYL-PEGACLONE.

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Logáil Isteach / Cláraigh

Purpose

5F-CUMYL-PEGACLONE is a recently emerged γ-carbolinone derived synthetic cannabinoid. The present study aimed to identify phase I metabolites to reliably prove consumption of the substance by urine analysis and to differentiate from the uptake of the

Cannabinoid Transmission in the Hippocampus Activates Nucleus Accumbens Neurons and Modulates Reward and Aversion-Related Emotional Salience.

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Logáil Isteach / Cláraigh

Cannabinoid receptor transmission strongly influences emotional processing, and disturbances in cannabinoid signaling are associated with various neuropsychiatric disorders. The mammalian ventral hippocampus (vHipp) is a critical neural region controlling mesolimbic activity via glutamatergic

Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD.

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Logáil Isteach / Cláraigh

Impairment of working memory is one of the most important deleterious effects of marijuana intoxication in humans, but its underlying mechanisms are presently unknown. Here, we demonstrate that the impairment of spatial working memory (SWM) and in vivo long-term depression (LTD) of synaptic strength

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Herbal & Natural Medicine

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