700 patients with AMI;several demographics, clinical and analytical parameters were collected, and peripheral blood and morning urine were collected from the patients and the volunteers after admission on the first, second, third and seventh days for DSS detection.Observe the dynamic changes of DSS level in acute ischemic cardiovascular disease of different severity. Adverse events (survival outcome) were observed and recorded in the hospital and at 1, 3, 6, and 12 months after discharge. Major adverse events mainly include disease recurrence, cardiac death and all-cause death. The newly established "circulatory integration" diagnosis and treatment evaluation system of acute ischemic cardiovascular with DSS as the core was used to predict the prognosis of patients with acute ischemic cardiovascular diseases.

500 patients with acute ischemic; several demographics, clinical and analytical parameters were collected,and peripheral blood and morning urine were collected from the patients and the volunteers after admission on the first, second, third and seventh days for DSS detection.Observe the dynamic changes of DSS level in acute ischemic cerebrovascular disease of different severity.Adverse events (survival outcome) were observed and recorded in the hospital and at 1, 3, 6, and 12 months after discharge. Major adverse events mainly include disease recurrence, cardiac death and all-cause death. The newly established "circulatory integration" diagnosis and treatment evaluation system of acute ischemic cardiovascular with DSS as the core was used to predict the prognosis of patients with acute cerebrovascular diseases.

500 patients with acute lower limb ischemia; several demographics, clinical and analytical parameters were collected,and peripheral blood and morning urine were collected from the patients and the volunteers after admission on the first, second, third and seventh days for DSS detection.Observe the dynamic changes of DSS level in lower limb ischemia disease of different severity.Adverse events (survival outcome) were observed and recorded in the hospital and at 1, 3, 6, and 12 months after discharge. Major adverse events mainly include disease recurrence, cardiac death and all-cause death. The newly established "circulatory integration" diagnosis and treatment evaluation system of lower limb ischemia disease with DSS as the core was used to predict the prognosis of patients with acute cerebrovascular diseases.

200 healthy volunteers were included as controls

Acute Myocardial Infarction

Acute Ischemic Stroke

Ischemic Cardiovascular Disease

Second Affiliated Hospital of Xi'an Jiaotong University

Shaanxi Provincial People's Hospital

First Affiliated Hospital Xi'an Jiaotong University

DSS's Role in Evaluating the Diagnosis and Treatment System of Ischemic Cardiovascular and Cerebrovascular Diseases

The Research on DSS in Evaluating the Diagnosis and Treatment System of Acute Ischemic Cardiovascular and Cerebrovascular Diseases

Incidence of disease recurrence，including acute myocardial infarction, ischemic stroke and acute lower limb ischemia.

All deaths were considered to have been from cardiac causes unless a explicit noncardiac cause could be documented.

All deaths were taken into account unless there is a definite cause of accidental death.

Intervention: A 20-hour dose of early intensive upper extremity motor training therapy will be initiated within 30 days post-stroke.

Intervention: A 20-hour dose of sub-acute intensive upper extremity motor training therapy will be initiated within 2 to 3 months post-stroke.

Intervention: A 20-hour dose of chronic intensive upper extremity motor training therapy will be initiated 6 to 9 months post-stroke

Intervention: Usual and customary care. No additional therapy will be initiated during the 1-year study.

Stroke

Brain Infarction

Brain Ischemia

Cerebral Infarction

Cerebrovascular Disorders

Using a shaping therapy protocol, participants will receive a dose of 20 hours of intensive upper extremity therapy (in addition to their current therapy) beginning within 30 days of stroke onset.

Early Intensive upper extremity motor training

Using a shaping therapy protocol, participants will receive a dose of 20 hours of intensive upper extremity therapy (in addition to their current therapy) beginning within 2 to 3 months post stroke.

Sub-acute intensive upper extremity motor training

Using a shaping therapy protocol, participants will receive a dose of 20 hours of intensive upper extremity therapy (in addition to their current therapy) beginning within 6 to 9 months post stroke.

Chronic intensive upper extremity motor training

Usual and Customary Care only. No additional therapy will be given during the 1-year study.

Control

MedStar National Rehabilitation Hospital

Critical Periods After Stroke Study (CPASS)

Critical Periods After Stroke Study (CPASS); Sensitive Periods and Consumer Preferences: Optimizing Upper Extremity Stroke Rehabilitation

The ARAT assesses functional limitations and evaluates changes in limb function for the upper extremity.

A structured interview to measure upper extremity use and function as well as assess the quality of movement of the hemiparetic arm.

A standardized quantitative test of upper extremity function and fine manual dexterity.

A basic indicator of severity of disability. Tracks changes in the functional ability of the patient during an episode of hospital rehabilitation care.

Measures performance in activities of daily living and functional disability.

To assess motor impairment and strength in the upper extremity.

A stroke-specific self-report to assess how stroke has impacted a person's life and their overall perception of recovery.

A self-report health status measure to assess perceived recovery with regard to the more affected hand and arm following a stroke.

A measure of the degree of disability or dependence in daily activities following a stroke.

An interview-based assessment used to measure an individual's participation in instrumental, leisure and social activities.

To assess quantitatively the degree that individuals who have experienced a traumatic injury or illness come to manage and reintegrate normal social activities with regard to recreation, movement at home and within the community, family and relationships.

A self-report assessment used to identify depressive symptoms in the elderly.

A systematic assessment used to evaluate and measure stroke-related. neurological impairments and stroke severity.

An assessment of cognitive ability and impairment.

An assessment used to evaluate visuospatial function and attention.

A performanced-based impairment index to assess motor function, sensation and joint function.

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DSS's Role in Evaluating the Diagnosis and Treatment System of Ischemic Cardiovascular and Cerebrovascular Diseases

Critical Periods After Stroke Study (CPASS)

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