sleep deprivation/hypoxia

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Leathanach 1 ó 343 torthaí

A review of the effects of hypoxia, sleep deprivation and transcranial magnetic stimulation on EEG activity in humans: challenges for drug discovery for Alzheimer's disease.

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Logáil Isteach / Cláraigh

Different kinds of challenge can alter cognitive process and electroencephalographic (EEG) rhythms in humans. This can provide an alternative paradigms to evaluate treatment effects in drug discovery. Here, we report recent findings on the effects of challenges represented by sleep deprivation (SD),

Performance impairment during four days partial sleep deprivation compared with the acute effects of alcohol and hypoxia.

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Logáil Isteach / Cláraigh

OBJECTIVE Subjects were exposed to cumulated partial sleep deprivation (psd), alcohol intake and hypoxia in a sequential design to examine the impact on neurobehavioral performance. METHODS Sixteen healthy male volunteers were enrolled in this study and were exposed in turn, after adaptation and

Intermittent hypoxemia and sleep fragmentation: associations with daytime alertness in obese sleep apnea patients living at moderate altitude.

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Logáil Isteach / Cláraigh

Although obstructive sleep apnea (OSA) has long been associated with daytime sleepiness, far less is known about its association with the ability to remain awake. The aim of this study was to examine the relative importance of inter-correlated measures of OSA severity (eg, various indices of oxygen

Sleep fragmentation and intermittent hypoxemia are associated with decreased insulin sensitivity in obese adolescent Latino males.

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Logáil Isteach / Cláraigh

BACKGROUND Although sleep-related breathing disorder (SRBD) has been linked to insulin resistance in adults, this has not been as well established in children. We hypothesized that the severity of SRBD in adolescents was associated with metabolic impairment. METHODS Polysomnography was performed on

Effects of pharmacological agents, sleep deprivation, hypoxia and transcranial magnetic stimulation on electroencephalographic rhythms in rodents: towards translational challenge models for drug discovery in Alzheimer's disease.

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Logáil Isteach / Cláraigh

Different kinds of challenge can alter spontaneous ongoing electroencephalographic (EEG) rhythms in animal models, thus providing paradigms to evaluate treatment effects in drug discovery. The effects of challenges represented by pharmacological agents, hypoxia, sleep deprivation and transcranial

Differential effect of intermittent hypoxia and sleep fragmentation on PD-1/PD-L1 upregulation.

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Logáil Isteach / Cláraigh

Immunosurveillance is compromised in obstructive sleep apnea (OSA) patients as reflected by overexpression of the programmed death cell receptor and its ligand (PD-1/PD-L1) co-inhibitory axis. However, the contributions of intermittent hypoxia (IH) and sleep fragmentation (SF) are unclear. We

Sleep deprivation under sustained hypoxia protects against oxidative stress.

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Logáil Isteach / Cláraigh

We previously showed that total sleep deprivation increased antioxidant responses in several rat brain regions. We also reported that chronic hypoxia enhanced antioxidant responses and increased oxidative stress in rat cerebellum and pons, relative to normoxic conditions. In the current study, we

Differential associations of hypoxia, sleep fragmentation and depressive symptoms with cognitive dysfunction in obstructive sleep apnoea

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Logáil Isteach / Cláraigh

Obstructive sleep apnoea (OSA) is characterized by recurrent episodes of partial or complete cessation of breathing during sleep and increased effort to breathe. This study examined patients who underwent overnight polysomnographic studies in a major sleep laboratory in Saudi Arabia. The study aimed

Hypoxemia vs sleep fragmentation as cause of excessive daytime sleepiness in obstructive sleep apnea.

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Logáil Isteach / Cláraigh

To determine the effects of intermittent hypoxemia on daytime sleepiness in the clinical setting of obstructive sleep apnea syndrome, we enrolled seven patients in a prospective, randomized, crossover study. We had two experimental conditions with NCPAP treatment as follow: (1) to correct apneas,

Distinct behavioral and neurochemical alterations induced by intermittent hypoxia or paradoxical sleep deprivation in rats.

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Logáil Isteach / Cláraigh

The current study investigated the effects of paradoxical sleep deprivation and intermittent hypoxia by examining whether a combination of the two would induce anxiety-like alterations in behavior. The neurochemical effects of these manipulations were investigated by measuring cortical, striatal and

Consequences of subchronic and chronic exposure to intermittent hypoxia and sleep deprivation on cardiovascular risk factors in rats.

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Logáil Isteach / Cláraigh

Since studies suggest that both hypoxia and sleep fragmentation are related to cardiovascular alterations induced by obstructive sleep apnea, the present study was designed to evaluate the effects of hypoxia, sleep deprivation, and their combination on biochemical blood parameters in rats. In

Spatial learning and memory deficits following exposure to 24 h of sleep fragmentation or intermittent hypoxia in a rat model of obstructive sleep apnea.

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Logáil Isteach / Cláraigh

Obstructive sleep apnea is primarily characterized by hypoxemia due to frequent apneic episodes and fragmentation of sleep due to the brief arousals that terminate the apneic episodes. Though neurobehavioral deficits frequently accompany sleep apnea, the relative roles of hypoxia versus sleep

Sleep-disordered breathing-related neurocognitive impairment, time to think beyond hypoxia and sleep fragmentation?

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Logáil Isteach / Cláraigh

Sleep apnoea related hypoxia is associated with cognitive disturbances in patients with tetraplegia.

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Logáil Isteach / Cláraigh

Sleep disordered breathing is common in patients with tetraplegia. Nocturnal arterial hypoxemia and sleep fragmentation due to sleep apnoea may be associated with cognitive dysfunction. We therefore studied the influence of sleep disordered breathing on neuropsychological function in 37

An Examination of Pain's Relationship to Sleep Fragmentation and Disordered Breathing Across Common Sleep Disorders.

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Logáil Isteach / Cláraigh

UNASSIGNED Short sleep duration and insomnia have been linked to higher pain and an increased risk of developing chronic pain, but relatively little research has examined the contribution of sleep disordered breathing (SDB) to pain. This study examined the unique contributions of SDB and insomnia to

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