A compound isolated from Ervatamia microphylla has been found to be effective in inducing a change in cell morphology and growth habits of cultured transformant cell lines, and in reducing the tumor size in a living mammal. The compound is capable of inhibiting the function of oncogenes such as ras and src by inhibiting the function of the oncogene products. The compound is found to be represented by formula (I): ##STR1## Use of the compound as an oncogene function inhibitor, in a treatment of cancer, and in inducing changes in cell morphology and growth habits in transformant cell line are contemplated.

Terumo Kabushiki Kaisha

Umezawa; Kazuo

tabernaemontana calcarea/ailse

Oncogene function-inhibitory agent, method for inhibiting oncogene function, and treatment of cancer

An bunachar luibheanna míochaine is iomláine le tacaíocht ón eolaíocht