xanthine dehydrogenase/murtall

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Teneligliptin Decreases Uric Acid Levels by Reducing Xanthine Dehydrogenase Expression in White Adipose Tissue of Male Wistar Rats.

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Logáil Isteach / Cláraigh

We investigated the effects of teneligliptin on uric acid metabolism in male Wistar rats and 3T3-L1 adipocytes. The rats were fed with a normal chow diet (NCD) or a 60% high-fat diet (HFD) with or without teneligliptin for 4 weeks. The plasma uric acid level was not significantly different between

Influence of overfeeding on growth, obesity and intestinal tract in young chicks of light and heavy breeds.

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Logáil Isteach / Cláraigh

1. Heavy-breed (HB) chicks differed from light-breed (LB) ones in their propensity to be overfed. Whereas in the LB chicks the amount by which they could be overfed reached 70% more than the food consumed daily by the ad lib.-fed chicks, in the HB chicks the maximal excess was only 13%. 2.

Dietary nicotinamide supplementation increases xanthine oxidoreductase activity in the kidney and heart but not liver of obese Zucker rats.

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Logáil Isteach / Cláraigh

The conversion of xanthine dehydrogenase to xanthine oxidase that produces oxygen radicals has been implicated in the ischemic injury to the myocardium and to the kidney. Xanthine dehydrogenase uses NAD as the electron acceptor to catalyze a reaction which does not produce any oxygen free radicals

Body mass index is independently associated with xanthine oxidase activity in overweight/obese population.

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Logáil Isteach / Cláraigh

OBJECTIVE The pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants of enlarged adipose tissue, we aimed to investigate the association between

Uric acid stones and hyperuricosuria.

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Logáil Isteach / Cláraigh

Recent work has highlighted the strong relationships among obesity, diabetes, and the metabolic syndrome as causes of low urinary pH. Low urinary pH in turn is the major urinary risk factor for uric acid stones. Unlike calcium stones, uric acid stones can be dissolved and easily prevented with

Effect of ethanol on metabolism of purine bases (hypoxanthine, xanthine, and uric acid).

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Logáil Isteach / Cláraigh

There are many factors that contribute to hyperuricemia, including obesity, insulin resistance, alcohol consumption, diuretic use, hypertension, renal insufficiency, genetic makeup, etc. Of these, alcohol (ethanol) is the most important. Ethanol enhances adenine nucleotide degradation and increases

New insights into purine metabolism in metabolic diseases: role of xanthine oxidoreductase activity

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Logáil Isteach / Cláraigh

Xanthine oxidoreductase (XOR) consists of two different forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO), and is a rate-limiting enzyme of uric acid production from hypoxanthine and xanthine. Uric acid is the end-product of purine metabolism in humans and has a powerful antioxidant

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Herbal & Natural Medicine

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