EGCG Improves Acne by Modulating Molecular Targets
कीवर्ड
सार
विवरण
Acne vulgaris is one of the most prevalent skin disorders of sebaceous follicles, affecting more than 85% of adolescents in United States. Acne can persist throughout the adulthood, and even a mild form of acne might progress to permanent scarring on the face, chest and back, thereby causing significant physical and psychosocial morbidities. Acne is a multifactorial disease of which etiology has not been fully elucidated, although considerable progress has been made in understanding its pathogenesis during last decade. The major pathogenic features of acne include abnormal ductal keratinization, sebum overproduction, Propionibacterium acnes, and inflammation. Common acne medications such as topical retinoids, antibiotics and isotretinoin are associated with irritation and incomplete responses, increased bacterial resistance or untoward side events, respectively. Thus there is a continuing need for a novel, effective agent targeting different aspects of acne pathogenesis, with minimal side effects.
In the recent decade, epigallocatechin-3-gallate (EGCG), the major polyphenolic constituent in green tea, has attracted much interest on account of its potent anti-carcinogenic, anti-inflammatory, anti-proliferative, and antimicrobial activities. Preclinical, observational, and clinical trial data have indicated that EGCG can inhibit tumor initiation, promotion, progression, and angiogenesis. EGCG also suppresses neutrophil chemotaxis, and has been suggested to improve many diseases that have inflammatory components such as diabetes, kidney injuries, arthritis, allergies, dental caries, cardiovascular, gastrointestinal, and neurodegenerative diseases. In skin, EGCG has been investigated mainly in light of antioxidative, immunopotentiating and anticarcinogenic properties against chemicals or ultraviolet irradiation. Moreover, EGCG has lipid-lowering and antiandrogenic properties, and can downregulate peroxisome proliferator-activated receptor-γ expression. Based on these observations, it can be inferred that EGCG might be effective in the treatment of acne.
खजूर
| अंतिम सत्यापित: | 08/31/2012 |
| पहले प्रस्तुत किया गया: | 07/22/2010 |
| अनुमानित नामांकन प्रस्तुत किया गया: | 09/12/2012 |
| पहले पोस्ट किया गया: | 09/18/2012 |
| अंतिम अद्यतन प्रस्तुत किया: | 09/12/2012 |
| अंतिम अद्यतन पोस्ट: | 09/18/2012 |
| वास्तविक अध्ययन प्रारंभ दिनांक: | 06/30/2005 |
| अनुमानित प्राथमिक समापन तिथि: | 05/31/2006 |
| अनुमानित अध्ययन पूर्णता तिथि: | 05/31/2006 |
स्थिति या रोग
हस्तक्षेप / उपचार
Other: topical EGCG application on acne
चरण
शाखा समूह
| बांह | हस्तक्षेप / उपचार |
|---|---|
| Active Comparator: Topical EGCG 1% Seventeen subjects were designated to use 1% EGCG .Since baseline visits, affected areas of randomly allocated half sides were treated with 1% solution twice daily, whereas those of the opposite sides were treated with vehicle only (3% ethanol). | |
| Experimental: topical EGCG 5% Eighteen subjects were designated to use 5% EGCG, to evaluate a dose-response relationship. Since baseline visits, affected areas of randomly allocated half sides were treated with 5% EGCG solution twice daily, whereas those of the opposite sides were treated with vehicle only (3% ethanol). |
पात्रता मापदंड
| युग अध्ययन के लिए पात्र | 15 Years सेवा 15 Years |
| सेक्स अध्ययन के लिए पात्र | All |
| स्वस्थ स्वयंसेवकों को स्वीकार करता है | हाँ |
| मानदंड | Inclusion Criteria: - age of at least 15 years - clinical diagnosis of mild to moderate acne vulgaris Exclusion Criteria: - known pregnancy or lactation - any medical illness that might influence the results of the study, - a previous history of oral acne medication or surgical procedures including laser treatment within 6 month and topical medication within 4 weeks of study enrollment. |
परिणाम
प्राथमिक परिणाम उपाय
1. Assessment of acne severity [8 week after baseline]
माध्यमिक परिणाम उपाय
1. 2-mm punch biopsy of acne lesion on the EGCG-treated sides [8 week after baseline]
2. Standardized clinical photographs [8 week after baseline]
