Glycemic Effects of Honey
कीवर्ड
सार
विवरण
Glucose intolerance and insulin resistance are associated with the development of the metabolic syndrome and chronic diseases, including, hyperlipidemia, hypertension, obesity, and type II diabetes. Current National Institutes of Health statistics estimate that 1 in 6 Americans have insulin resistance (www.diabetes.niddk.nih.gov/dm/pubs/statistics). Insulin resistance in humans is associated with glucose intolerance, enhanced oxidative stress, inflammation and alterations in lipid profiles. Improvements in glucose tolerance are associated with improved insulin sensitivity resulting in improved inflammatory and oxidative status. Dietary modification to reduced day-long serum insulin concentration is postulated to decrease hepatic cholesterol production through inhibition of HMG CoA reductase, the rate limiting enzyme involved in cholesterol synthesis.
Maintenance of normal blood glucose is dependent on the body's ability to modulate insulin secretion in response to the glucose load consumed. Although diet may be an important factor in glucose tolerance, the role of nutritive sweeteners has not been clearly defined. Much research has been performed on the effect of dietary sugars on chronic disease risk factors, including animal studies, and human studies ranging from epidemiologic to controlled feeding trials with most of this work focused on the monosaccharides: fructose and glucose or the disaccharide, sucrose.
Little work has been done on the comparative effects of honey and other nutritive sweeteners in relation to glucose tolerance and insulin sensitivity.
खजूर
अंतिम सत्यापित: | 07/31/2018 |
पहले प्रस्तुत किया गया: | 06/02/2011 |
अनुमानित नामांकन प्रस्तुत किया गया: | 06/07/2011 |
पहले पोस्ट किया गया: | 06/09/2011 |
अंतिम अद्यतन प्रस्तुत किया: | 07/31/2018 |
अंतिम अद्यतन पोस्ट: | 08/02/2018 |
वास्तविक अध्ययन प्रारंभ दिनांक: | 05/31/2011 |
अनुमानित प्राथमिक समापन तिथि: | 11/30/2014 |
अनुमानित अध्ययन पूर्णता तिथि: | 07/31/2015 |
स्थिति या रोग
हस्तक्षेप / उपचार
Dietary Supplement: Honey
Dietary Supplement: High Fructose Corn Syrup 55 (HFCS 55)
Dietary Supplement: CHO (sugar)
चरण
शाखा समूह
बांह | हस्तक्षेप / उपचार |
---|---|
Active Comparator: Honey 60.7 grams daily orally times 14 days | |
Active Comparator: CHO 50 grams daily orally times 14 days | |
Active Comparator: High Fructose Corn Syrup 65.7 grams daily orally times 14 days |
पात्रता मापदंड
युग अध्ययन के लिए पात्र | 20 Years सेवा 20 Years |
सेक्स अध्ययन के लिए पात्र | All |
स्वस्थ स्वयंसेवकों को स्वीकार करता है | हाँ |
मानदंड | Inclusion Criteria: 1. Men and women between 20-80 years of age. 2. Normal Glucose Tolerance - Fasting glucose between ≤105 mg/dl - Normal body weight or overweight (BMI 18-29.9) 3. Impaired Glucose Tolerance - Fasting glucose between 106-125 mg/dl - Overweight or obese (BMI 25 - 39.9) 4. Willingness to comply with the demands of the experimental protocol 5. Sedentary Lifestyle Exclusion Criteria: 1. Known uncontrolled disease process 2. Diabetes mellitus 3. Use of medications that affect glucose metabolism 4. History of an eating disorder 5. Pregnancy or breast feeding 6. Inability to give consent 7. Unwillingness or inability to consume the supplemental sugars |
परिणाम
प्राथमिक परिणाम उपाय
1. Area under the curve glucose, response for OGTT. Glucose-120 min OGTT-AUC [15 weeks]
माध्यमिक परिणाम उपाय
1. Insulin- 120 min OGTT - AUC [15 weeks]
2. Triglycerides - 120 min OGTT - AUC [15 weeks]
3. Inflammatory Markers [15 weeks]
4. Oxidative Stress Markers [15 weeks]
5. Serum Lipids [15 weeks]