Vertebral Bone Marrow Lesions by DWI and ADC Values
कीवर्ड
सार
विवरण
MRI has a high sensitivity in delineating the pathology, its specificity is low. Osteoporotic and metastatic compression fractures may be mistaken for each other in the acute phase (Wong and Suresh, 2018). Edema in the acute phase of benign fractures may replace normal bone marrow and cause hypointense signal changes in T1-weighted images and hyperintense signal changes in T2-weighted images, at the same time taking contrast material. These changes are also typical for metastasis and cause confusion in diagnosis when only one lesion is present (Mauch et al., 2018).
Diffusion-weighted imaging (DWI) has recently appeared as a new method of screening in characterizing lesions without necessitating contrast material and in evaluating the vertebrae quantitatively (Lee et al., 2019) Diffusion-weighted-imaging (DWI) provides microscopic information from water protons which is not possible using conventional magnetic resonance imaging (MRI) (Partridge et al., 2017). DWI measures the random (Brownian) extra, intra and transcellular motion of water molecules (Ahlawat and Fayad, 2018) Apparent-diffusion-coefficient (ADC) is a quantitative parameter calculated from DWI that combines the effects of capillary perfusion and water diffusion (Wang et al., 2018) In a comparatively small number of surveys, ADC values have been studied in discriminating the infectious lesions from the malign lesions The utility of apparent diffusion coefficient obtained in diffusion-weighted MR imaging for the differentiation between benign and malignant vertebral lesions, and to determine the sensitivity and the specificity in differentiating benign and malignant vertebral lesions according to the optimal cutoff ADC value (Dahnert et al., 2017)
खजूर
अंतिम सत्यापित: | 05/31/2020 |
पहले प्रस्तुत किया गया: | 06/10/2020 |
अनुमानित नामांकन प्रस्तुत किया गया: | 06/11/2020 |
पहले पोस्ट किया गया: | 06/15/2020 |
अंतिम अद्यतन प्रस्तुत किया: | 06/11/2020 |
अंतिम अद्यतन पोस्ट: | 06/15/2020 |
वास्तविक अध्ययन प्रारंभ दिनांक: | 06/30/2020 |
अनुमानित प्राथमिक समापन तिथि: | 06/30/2021 |
अनुमानित अध्ययन पूर्णता तिथि: | 07/31/2021 |
स्थिति या रोग
हस्तक्षेप / उपचार
Device: MRI including conventional MRI, DWI with multiple ADC values
चरण
पात्रता मापदंड
युग अध्ययन के लिए पात्र | 18 Years सेवा 18 Years |
सेक्स अध्ययन के लिए पात्र | All |
नमूनाकरण विधि | Non-Probability Sample |
स्वस्थ स्वयंसेवकों को स्वीकार करता है | नहीं |
मानदंड | Inclusion Criteria: After taking clinical complaint and Orthopedic and neurological examinations, all patients (any age or sex) with suspected bone marrow focal lesions will undergo DWI and ADC map. Exclusion Criteria: All patients who contraindicated for MRI study as patients with cardiac pacemaker, any metallic stent, claustrophobia and morbid obesity. |
परिणाम
प्राथमिक परिणाम उपाय
1. The utility of apparent diffusion coefficient obtained in diffusion-weighted MR imaging [6 months]
माध्यमिक परिणाम उपाय
1. Sensitivity, specificity and predictive value of the procedure [6 months]