The Acute Effect of Spices on Vascular Health
Ključne riječi
Sažetak
Opis
A 3-period randomized controlled crossover study will be conducted to investigate the postprandial effects of a high fat meal with spices on endothelial function, lipids/lipoproteins, immune function, plasma antioxidants and markers of oxidative stress. Metabolomic profiling will also be conducted. In random order participants will consume either a high fat meal (1000kcal, 45g fat) or a high fat meal containing 2g of spices or a high fat meal containing 6g of spices with a 3 day washout period between each treatment. The following spices will be incorporated into the meal black pepper, basil, bay leaf, cinnamon, coriander, cumin, ginger, oregano, parsley, rosemary, red pepper, turmeric and thyme.
Endothelial function will be measured by flow mediated dilation of the brachial artery in the fasting state and 2 and 4 hours after the meal. Participants will also provide a fasting blood sample and samples will also be taken at 1, 2, 3 and 4 hours after the meal.
Datumi
| Posljednja provjera: | 04/30/2019 |
| Prvo podneseno: | 09/13/2016 |
| Predviđena prijava poslana: | 02/20/2017 |
| Prvo objavljeno: | 02/26/2017 |
| Posljednje ažuriranje poslano: | 05/13/2019 |
| Posljednje ažuriranje objavljeno: | 05/15/2019 |
| Stvarni datum početka studija: | 09/12/2016 |
| Procijenjeni datum primarnog završetka: | 03/28/2018 |
| Procijenjeni datum završetka studije: | 03/28/2018 |
Stanje ili bolest
Intervencija / liječenje
Other: Herbs and spices
Other: High fat meal
Faza
Grupe ruku
| Ruka | Intervencija / liječenje |
|---|---|
| Active Comparator: Control Consumption of a high fat meal (1000kcal, 45g fat) | |
| Experimental: Spice 2g Consumption of a high fat meal (1000kcal, 45g fat) with 2g of spice (mix of black pepper, basil, bay leaf, cinnamon, coriander, cumin, ginger, oregano, parsley, rosemary, red pepper, turmeric and thyme) incorporated into the meal. | |
| Experimental: Spice 6g Consumption of a high fat meal (1000kcal, 45g fat) with 6g of spice (mix of black pepper, basil, bay leaf, cinnamon, coriander, cumin, ginger, oregano, parsley, rosemary, red pepper, turmeric and thyme) incorporated into the meal. |
Kriterij prihvatljivosti
| Dobni uvjeti za studiranje | 40 Years Do 40 Years |
| Spolovi koji ispunjavaju uvjete za studij | Male |
| Prihvaća zdrave volontere | Da |
| Kriteriji | Inclusion Criteria: - male aged 40-65 years - BMI 25-35kg/m2 - nonsmoking - waist circumference =/> 94cm and at least one other CVD risk factor (elevated LDL-C (> 130 mg/dL), CRP (> 1 mg/L), elevated Triglycerides (≥ 150 mg/dL), reduced HDL-cholesterol (< 40 mg/dL), elevated blood pressure (systolic BP ≥ 130 or diastolic BP ≥ 85 mm Hg), elevated fasting glucose (≥ 100 mg/dL)) - low herb/spice consumers (consumption <1/day) Exclusion Criteria: - Chronic disease risk factors that are diagnostic of diabetes (fasting glucose > 126 mg/dL) or hypertension (SBP >160 mm Hg or DBP > 100 mm Hg). - Prescription of anti-hypertensive or glucose lowering drugs. - Established CVD, stroke, diabetes, liver, kidney or autoimmune disease - Use of cholesterol/lipid-lowering medication or supplements (psyllium, fish oil, soy lecithin, and phytoestrogens) and botanicals - weight loss of ≥10% of body weight within the 6 months prior to enrolling in the study - vegetarianism |
Ishod
Primarne mjere ishoda
1. Change in endothelial function measured by flow mediated dilation (FMD) of the brachial artery [Change from baseline at 2 hours and 4 hours after meal consumption]
Sekundarne mjere ishoda
1. Lipids and lipoproteins [Change from baseline during the 4 hours after meal consumption]
2. Plasma Inflammatory cytokines [Change from baseline during the 4 hours after meal consumption]
3. Inflammatory cytokines in isolated peripheral blood mononuclear cells [Change from baseline during the 4 hours after meal consumption]
4. Glucose [Change from baseline during the 4 hours after meal consumption]
5. Insulin [Change from baseline during the 4 hours after meal consumption]
6. Plasma antioxidants (hydrophilic ORAC, lipophilic ORAC, total ORAC) [Change from baseline during the 4 hours after meal consumption]
7. Oxidative stress [Change from baseline during the 4 hours after meal consumption]
8. Plasma nitrite and nitrate [Change from baseline during the 4 hours after meal consumption]
9. Plasma and Urine Metabolomic profiling [Change from baseline during the 4 hours after meal consumption]
