Different Factors Affecting Patients With Newly Diagnosed Bladder Cancer
Ključne riječi
Sažetak
Opis
OBJECTIVES:
- To assess the effect of lifestyle factors (e.g., smoking, dietary habits, fluid intake, or environmental exposures) on the recurrence and progression of bladder cancer.
- To assess the impact of selenium and/or vitamin E on the progression and recurrence of bladder cancer.
- To study health-related quality of life and its association with recurrence and progression of bladder cancer.
- To establish a bladder cancer tissue bank that will comprise blood, urine, and bladder tissue.
- To study the predictive effect of molecular markers on the recurrence and progression of bladder cancer.
OUTLINE: This is a multicenter study.
The study will be based on a cohort of patients with newly detected bladder cancer in all 16 urological centres within the West Midlands, commencing in late 2005 for a period of 5 years. This research project consists of 5 individual studies: CRUK-BCPP-2005-01-COHORT, CRUK-BCPP-2005-01-MARKERS, CRUK-BCPP-2005-01-QOL, CRUK-BCPP-2005-01-TISSUE-BANK, and CRUK-BCPP-2005-01-TREATMENT. Patients may participate in all or only some of these individual studies.
Peer Reviewed and Funded or Endorsed by Cancer Research UK.
Datumi
| Posljednja provjera: | 09/30/2007 |
| Prvo podneseno: | 11/01/2007 |
| Predviđena prijava poslana: | 11/01/2007 |
| Prvo objavljeno: | 11/03/2007 |
| Posljednje ažuriranje poslano: | 01/08/2014 |
| Posljednje ažuriranje objavljeno: | 01/09/2014 |
| Stvarni datum početka studija: | 11/30/2005 |
Stanje ili bolest
Intervencija / liječenje
Drug: selenium
Drug: vitamin E
Procedure: biopsy
Procedure: chemoprevention
Procedure: cryopreservation
Procedure: cytology specimen collection procedure
Procedure: diagnostic procedure
Procedure: gene expression analysis
Procedure: immunohistochemistry staining method
Procedure: laboratory biomarker analysis
Procedure: medical chart review
Procedure: mutation analysis
Procedure: polymerase chain reaction
Procedure: quality-of-life assessment
Procedure: questionnaire administration
Procedure: study of socioeconomic and demographic variables
Faza
Kriterij prihvatljivosti
| Dobni uvjeti za studiranje | 18 Years Do 18 Years |
| Spolovi koji ispunjavaju uvjete za studij | All |
| Prihvaća zdrave volontere | Da |
| Kriteriji | DISEASE CHARACTERISTICS: - Bladder lesion with cystoscopic characteristics compatible with urothelial cancer or transitional cell carcinoma meeting 1 of the following criteria: - Non-muscle-invasive tumor - Muscle-invasive tumor - Solitary G1 pTa tumor - No previous diagnosis of cancer of the urethra, bladder, ureter, or renal pelvis within the 10 years prior to current diagnosis PATIENT CHARACTERISTICS: - Fit for cystoscopy and surgical biopsy/resection - No HIV infection - No condition that, in the opinion of the local investigator, might interfere with the safety of the patient or evaluation of the study objectives PRIOR CONCURRENT THERAPY: - Not specified |
Ishod
Primarne mjere ishoda
1. Recurrence-free interval [undefined]
2. Progression-free interval [undefined]
Sekundarne mjere ishoda
1. Overall survival time [undefined]
2. Incidence of transitional cell carcinoma outside the bladder [undefined]
3. Incidence of all other malignancies clinically diagnosed [undefined]
4. Incidence of cardiovascular events [undefined]
5. Quality of life as measured by EORTC QLQ-C30, QLQ-BLS24 and QLQ-BLM30 questionnaires [undefined]
