Effect of Atazanavir on Endothelial Function in HIV-Infected Patients
Ključne riječi
Sažetak
Opis
Indication: Dyslipidemia Type II in HIV-Infected Patients
Primary Objectives: Change of flow-mediated dilation in the forearm after 6 months using the protease inhibitor atazanavir in a potent antiviral therapy combination compared with a combination including current proteinase inhibitor.
Secondary Objectives: Changes in plasma lipid profiles and further clinical chemistry parameters after 6 months of treatment compared to baseline.
Study Design: This is a multicenter, observer-blind (measurements of vessel parameters and statistical evaluation), treatment-controlled, randomized, study with 2 treatment groups.
Planned Total Sample Size: (40-50) eligible randomized patients (20-25 per group) from 2-5 centers.
Subject Selection Criteria:
- Men and women, 18 to 65 years old.
- HIV-infection, documented by HIV-antibody ELISA and either positive immunoblot for HIV-antibodies or presence of HIV1 in blood.
- Two consecutive Roche Ultrasensitive Amplicor tests showing plasma HIV-1 RNA < 50 copies/ml within 60 days prior to study entry.
- CD4 count of > 100 cells/ml during 60 days prior to study entry.
- Stable antiretroviral therapy for at least 12 weeks prior to study entry (a protease inhibitor plus 2 NRTIs).
- Patient's treatment history allows, in the opinion of the investigator, atazanavir as replacement for current PI, i.e. continued viral suppression is expected based upon patient's treatment history and results of previous resistance testing, if available.
- Fasting LDL-cholesterol > 3.0 mmol/l.
Contraindications for participation:
- Known coronary artery disease, hypertension, peripheral artery disease, or cerebrovascular disease.
- Diabetes mellitus.
- Serious illness requiring systemic treatment and/or hospitalization within 14 days prior to study entry.
- Any contraindication for study medication.
- Currently on non-nucleoside reverse transcriptase inhibitors (NNRTI) (previous exposure allowed).
- Previous virologic failure on proteinase inhibitor-containing regimens which was not the consequence of poor adherence to therapy or drug adverse events; i.e. virologic failure was probably due to lack of potency of drug regimen, and may consecutively have resulted in protease resistance mutations.
- Previously documented protease resistance mutations which are known to result in cross-resistance against atazanavir.
- Any lipid lowering drugs within 4 weeks prior to study entry.
- Testosterone or anabolic steroids unless stable therapy at least 12 weeks prior to study entry.
- Systemic glucocorticoids, long-acting inhaled steroids or other immunomodulators within 30 days prior to study entry (prednisone < 10mg/day or equivalent is permitted.
- Drug or alcohol abuse, in the opinion of the investigator rendering the patient unreliable for participation.
- Participation in any other drug/treatment study.
Test Drugs:
1. Atazanavir capsules in daily standard dose (2 x 200 mg once daily) or
2. Continuation of current protease inhibitor
Datumi
| Posljednja provjera: | 02/28/2007 |
| Prvo podneseno: | 03/11/2007 |
| Predviđena prijava poslana: | 03/12/2007 |
| Prvo objavljeno: | 03/13/2007 |
| Posljednje ažuriranje poslano: | 05/25/2009 |
| Posljednje ažuriranje objavljeno: | 05/26/2009 |
| Stvarni datum početka studija: | 07/31/2004 |
| Procijenjeni datum završetka studije: | 04/30/2006 |
Stanje ili bolest
Intervencija / liječenje
Drug: ATAZANAVIR
Faza
Kriterij prihvatljivosti
| Dobni uvjeti za studiranje | 18 Years Do 18 Years |
| Spolovi koji ispunjavaju uvjete za studij | All |
| Prihvaća zdrave volontere | Da |
| Kriteriji | Inclusion Criteria: - Men and women, 18 to 65 years old. - HIV-infection, documented by HIV-antibody ELISA and either positive immunoblot for HIV-antibodies or presence of HIV1 in blood. - Two consecutive Roche Ultrasensitive Amplicor tests showing plasma HIV-1 RNA < 50 copies/ml within 60 days prior to study entry. - CD4 count of > 100 cells/ml during 60 days prior to study entry. - Stable antiretroviral therapy for at least 12 weeks prior to study entry (a protease inhibitor plus 2 NRTIs). - Patient's treatment history allows, in the opinion of the investigator, atazanavir as replacement for current PI, i.e. continued viral suppression is expected based upon patient's treatment history and results of previous resistance testing, if available. - Fasting LDL-cholesterol > 3.0 mmol/l. Exclusion Criteria: - Known coronary artery disease, hypertension, peripheral artery disease, or cerebrovascular disease. - Diabetes mellitus. - Serious illness requiring systemic treatment and/or hospitalization within 14 days prior to study entry. - Any contraindication for study medication. - Currently on non-nucleoside reverse transcriptase inhibitors (NNRTI) (previous exposure allowed). - Previous virologic failure on proteinase inhibitor-containing regimens which was not the consequence of poor adherence to therapy or drug adverse events; i.e. virologic failure was probably due to lack of potency of drug regimen, and may consecutively have resulted in protease resistance mutations. - Previously documented protease resistance mutations which are known to result in cross-resistance against atazanavir. - Any lipid lowering drugs within 4 weeks prior to study entry. - Testosterone or anabolic steroids unless stable therapy at least 12 weeks prior to study entry. - Systemic glucocorticoids, long-acting inhaled steroids or other immunomodulators within 30 days prior to study entry (prednisone < 10mg/day or equivalent is permitted. - Drug or alcohol abuse, in the opinion of the investigator rendering the patient unreliable for participation. - Participation in any other drug/treatment study. |
Ishod
Primarne mjere ishoda
1. Change of flow-mediated dilation in the forearm after 6 months using the protease inhibitor atazanavir in a potent antiviral therapy combination compared with a combination including current proteinase inhibitor. [undefined]
Sekundarne mjere ishoda
1. Changes in plasma lipid profiles and further clinical chemistry parameters after 6 months of treatment compared to baseline. [undefined]
