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Phytotherapy Research 1999-Dec

The pharmacological effects of an aqueous extract from Acacia nilotica seeds.

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Veza se sprema u međuspremnik
S Amos
P A Akah
C J Odukwe
K S Gamaniel
C Wambede

Ključne riječi

Sažetak

An aqueous extract of the seed of Acacia nilotica was investigated for its pharmacological profile. On the isolated guinea-pig ileum, the extract displayed sustained dose-related contractile activity. The contractions which were reduced by hexamethonium, promethazine or atropine were completely abolished by nifedipine. The intravenous (i.v.) administration of the extract (11, 22, 44, 55 microg/kg) to anaesthetized cats produced a dose-related significant elevation of blood pressure. The mechanisms of the spasmogenic and vasoconstrictor actions of the extract have not been determined, however, the results suggest the involvement of calcium.

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