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[Glucomannan: properties and therapeutic applications].

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Glucomannan is a dietary fiber employed quite frequently in the western countries since two decades now, as its ingestion plays an important role in human health. However, eastern people have used this fiber for more than a thousand years. This dietary fiber is the main polysaccharide obtain from

The use of konjac glucomannan hydrolysates to recover healthy microbiota in infected vaginas treated with an antifungal agent.

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The aim of this study was to evaluate how konjac glucomannan hydrolysates (GMH) could support the healthy re-colonisation of vaginal microflora post infections. A total of 26 female patients (12 controls and 14 treatments) aged 18 to 25 suffering from vaginal infection were recruited for this study.

Antibacterial, antifungal and cytotoxic activities of amblyone isolated from Amorphophallus campanulatus.

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OBJECTIVE To assess the in vitro antibacterial, antifungal and cytotoxic activities of amblyone, a triterpenoid isolated from Amorphophallus campanulatus (Roxb). METHODS Disc diffusion technique was used for in vitro antibacterial and antifungal screening. Cytotoxicity was determined against brine

Hypoglycemic and antioxidant properties of konjac (Amorphophallus konjac) in vitro and in vivo

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The aim of this study was to evaluate the hypoglycemic and antioxidant potential of konjac in vitro and in vivo. Glucose diffusion and enzymatic starch digestion of konjac were assayed using α-amylase and α-glucosidase. Oral glucose tolerance test (OGTT) and oral starch tolerance test (OSTT) were

Beneficial health characteristics of native and hydrolysed konjac (Amorphophallus konjac) glucomannan.

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The impact of ingesting glucomannans on health is not limited to colonic-focused fermentation into short-chain fatty acids (SCFAs), which might have some local health benefits; it also helps in treating disease states and enhancing the body's immune system, both within the gut and in/on other parts

The use of konjac glucomannan to lower serum thyroid hormones in hyperthyroidism.

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OBJECTIVE Patients with hyperthyroidism occasionally need rapid restoration to the euthyroid state. In view of the increased enterohepatic circulation of thyroxine (T4) and triiodothyronine (T3) in thyrotoxicosis, and metabolic effects of konjac glucomannan in gastrointestinal system, we aimed to

Konjac-Mannan and American ginsing: emerging alternative therapies for type 2 diabetes mellitus.

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Despite significant achievements in treatment modalities and preventive measures, the prevalence of diabetes has risen exponentially in the last decade. Because of these limitations there is a continued need for new and more effective therapies. An increasing number of people are using dietary and

Beneficial effects of konjac powder on lipid profile in schizophrenia with dyslipidemia: A randomized controlled trial

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Background and objectives: Konjac powder has the effect of improving blood lipids in the general population, but there is no research on schizophrenic patients who are susceptible to dyslipidemia. The aim of our study is to evaluate the

Beneficial effects of viscous dietary fiber from Konjac-mannan in subjects with the insulin resistance syndrome: results of a controlled metabolic trial.

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OBJECTIVE Dietary fiber has recently received recognition for reducing the risk of developing diabetes and heart disease. The implication is that it may have therapeutic benefit in prediabetic metabolic conditions. To test this hypothesis, we investigated the effect of supplementing a

In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy.

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The aim of this study was to prepare, characterize novel types of pH-sensitive konjac gum-xanthan gum-glycerol-sodium alginate hydrogel (KGM-XG-GLY-SA hydrogel) allowing for the site-specific delivering of drugs to the colon and evaluate its colon-targeting characteristic. In this study, hydrophilic

Curative effect of Amorphophallus paeoniifolius tuber on experimental hemorrhoids in rats.

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BACKGROUND Amorphophallus paeoniifolius (Dennst.) Nicolson (Family- Araceae) is a crop of south East Asian origin. In India, its tuber is widely used in ethnomedicinal practices by different tribes for the treatment of piles (hemorrhoids). OBJECTIVE The present study evaluated the effect of

An orally administrated nucleotide-delivery vehicle targeting colonic macrophages for the treatment of inflammatory bowel disease.

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Tumor necrosis factor-alpha (TNF-α) plays a central role in the pathogenesis of inflammatory bowel disease (IBD). Anti-TNF-α therapies have shown protective effects against colitis, but an efficient tool for target suppression of its secretion - ideally via oral administration - remains in urgent

Effect of konjac glucomannan hydrolysates and probiotics on the growth of the skin bacterium Propionibacterium acnes in vitro.

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The synbiotic ability of probiotic bacteria and konjac glucomannan hydrolysates (GMH) to inhibit acne-inducing bacterium, Propionibacterium acnes growth was studied in vitro. All probiotic bacteria strains tested were able to inhibit the growth of this species of skin bacterium where the inhibition

Glucomannan for abdominal pain-related functional gastrointestinal disorders in children: a randomized trial.

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OBJECTIVE To assess the efficacy of glucomannan (GNN) as the sole treatment for abdominal pain-related functional gastrointestinal disorders (FGIDs). METHODS We conducted a double-blind, placebo-controlled, randomized trial. Patients were recruited among children referred to the Department of

A Systematic Review Exploring the Anticancer Activity and Mechanisms of Glucomannan.

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Glucomannan, long recognized as the active ingredient of the traditional Chinese medicinal herb Konjac glucomannan, is a naturally occurring polysaccharide existing in certain plant species and fungi. Due to its special property to also serve as a dietary supplement, glucomannan has been widely

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