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A simple and rapid method for isolation of andrographolide from the leaves of Andrographis paniculata is reported. This involves extraction of the leaf powder by cold maceration in a 1:1 mixture of dichloromethane and methanol and isolation of andrographolide directly from the resulting extract by
The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity. The extract significantly reduced coronary perfusion pressure by up to 24.5 ± 3.0 mm Hg at a 3 mg dose and also reduced heart rate by up to 49.5 ± 11.4 beats/minute at this dose. Five labdane
Andrographis paniculata extract is traditionally used as a medicine to treat different diseases in India, China and Southeast Asia. In the present study, we evaluated the anticancer and immunomodulatory activity of the methanolic extract of Andrographis paniculata in human cancer and immune cells.