Combination of the conventional drugs and Jobelyn

Combination of the conventional drug + Placebo

Schizophrenia and Disorders With Psychotic Features

Jobelyn is a dietary supplement made from Sorghum bicolor

Jobelyn

Conventional drug normally used for psychotic problems

Haloperidol

Federal Neuro-Psychiatric Hospital Yaba - Lagos

Antipsychotic Effects of Sorghum Bicolor (JOBELYN) in the Treatment of Schizophrenia

Phase 2 Study of the Antipsychotic Effects of Sorghum Bicolor (JOBELYN) in the Treatment of Schizophrenia.

This will be rated using the Brief Psychiatric Rating Scale (BPRS).

To be assessed using the Clinical Global Impression Scale.

This will be measured using a side-effect scale designed for the study

Federal Neuro-Psychiatric Hospital, Yaba

The intervention visit involves a test meal to be consumed by subjects attending the Human Nutrition Unit in the morning, following an overnight fast. The meal will be consumed within 15 minutes and blood (69 mL) and urine samples will be collected during 24 hours.
The test meals are designed to contain the same amount of proteins. Alternative protein meals: a number of bread buns for each meal containing individual alternative protein flours (green pea, lupin, hemp, buckwheat, fava beans). These will deliver 30 g of protein, the remainder being provided by white flour. The control (meat) meal: a lean beef steak containing 30 g of protein and a bun containing the same amount of white flour as used for the alternative protein bread buns.
The semi structured interview guide: will take place within the Human Nutrition Unit during one of the scheduled visits, once initial screening has taken place and participants have been selected. All interviews will be digitally recorded.

Healthy

Fava bean, Lupin, Beef meat, Green pea, Hemp, Buckwheat

Rowett Institute of Nutrition and Health, University of Aberdeen

Health Impacts of Sustainable Ingredient Selection in the Food and Drink Industry - ALTERNATIVE PROTEIN STUDY

Each intervention visit will involve a test meal to be consumed by subjects attending the Human Nutrition Unit (HNU) in the morning, following an overnight fast. They will be provided with a meal, which will be consumed within 15 minutes and blood (69 mL) and urine samples will be collected during 24 hours .
Biomarkers of satiety as measured by gut-related hormones and subjective appetite using visual analogue scales, specifically to be collected during the meal over a three hour period, every 30 minutes. The energy intake measured for each volunteer after an ad libitum lunch (five hours after test meal).
Biomarkers of CVD risk including total cholesterol, low density lipoproteins (LDL), high density lipoproteins (HDL), triglycerides and non-esterified fatty acids (NEFA).
Assessment of peripheral glycaemic control, fasting glucose, area under the curve combined with insulin data.

The intervention visit will involve a test meal to be consumed by subjects attending the Human Nutrition Unit (HNU) in the morning, following an overnight fast. They will be provided with a meal, which will be consumed within 15 minutes and blood (69 mL) and urine samples will be collected during 24 hours
Plasma and urine markers of important phytochemical and protein metabolites will be quantitatively analysed to determine the systemic availability, in vivo concentrations and excretion times.

With regard to the social science component of the project, in-depth semi-structured interviews will be used for assessing the volunteers view towards diets rich in alternative plant proteins. For each volunteer will be conducted an digitally recorded interview(one hour), during one of the scheduled visits at the Human Nutrition Unit, once initial screening has taken place and participants have been selected.

University of Aberdeen

Cyclophosphamide- Epirubicin 6 course regimen to be used with Jobelyn

Routine drugs for treatment of Breast Cancer used with Placebo

Haematological Abnormality

Jobelyn (dietary Supplement) to be used with Cyclophosphamide-Epirubicin6

Jobelyn + Cyclophosphamide-Epirubicin6

Routine drugs for the treatment of breast cancer to be used with Placebo

Placebo + Cyclophosphamide - Epirubicin 6

Lagos State University Teaching Hospital

Lagos State University

The Safety and Efficacy of Jobelyn in the Treatment of Breast Cancer Patients

A Prospective Phase II Randomized, Blinded Study to Demonstrate the Effectiveness of Jobelyn for the Treatment of Breast Cancer Patients.

Evaluation of the expression of activated natural killer cells CD3-CD56+CD69+ after treatment with Jobelyn

Subjects would use form Safety Fractor-36 to score aspects of well-being

Changes in levels of hematocrit after treatment with Jobelyn

Abiodun Popoola

CONSULTANT IN THE DEPARTMENT OF ONCOLOGY LASUTH

PQG means Piperine, Quercetin and Genistein

Subjects will consume bread added with free curcumin

All participants followed all the periods

All Study Participants

Sex: Female, Male

Region of Enrollment

Area Under the Curves (AUC) from 0 to 24h of parent polyphenols was calculated using a trapezoidal rule applied to the concentration-time curves of compounds.

subjects consumed bread enriched with free curcumin

Free Curcumin

subjects consumed bread enriched with encapsulated curcumin

Encapsulated Curcumin

subjects consumed bread enriched with encapsulated curcumin plus piperine, quercetin and genistein

Encapsulated Curcumin + PQG

Control Cream

subjects consumed cocoa-nut cream enriched with cocoa polyphenols in the free form

Free Cocoa Polyphenols

subjects consumed cocoa-nut cream enriched with encapsulated cocoa polyphenols

Encapsulated Cocoa Polyphenols

Serum Polyphenol Concentrations Over 24h From Food Consumption

Area Under the Curve (AUC) from 0 to 24h of total polyphenols (sum of parent polyphenols and metabolites)was calculated using a trapezoidal rule applied to the urinary concentration-time curves of compounds.

subjects consumed bread containing encapsulated curcumin

subjects consumed bread containing encapsulated curcumin plus PQG (i.e. Piperine, Quercetin and Genistein)

subjects consumed nut creams added with cocoa polyphenols

Free Cocoa Polyphenol

Subjects consumed white bread or nut cream

Control

subjects consumed nut creams added with encapsulate cocoa-polyphenols

Subjects consumed bread added with free curcumin

Urinary Excretion of Total Polyphenols

Amount of parent polyphenols and metabolites in feces was calculated by multiplying net concentrations by the amount of feces.

Amount of Total Fecal Polyphenols

Subjects consumed 2 bread portions/day of bread enriched with micro-encapsulated curcumin(1g/100g portion, i.e. 2g/day)

Subjects consumed 2 bread portions/day of bread enriched with micro-capsules containing curcumin at dosage of 1 g/100 g plus 0.1% of Piperine, Quercetin and Genistein (PQG) (2g curcumin + 0.2g PQG/day) for one day.

Subjects consumed 3 nut cream portions (33g each) enriched with cocoa polyphenols at dosage of 1.5g/day.

Subjects consumed 3 nut cream portions (33g each).

Subjects consumed 3 nut cream portions (33g each) enriched with encapsulated cocoa polyphenols at dosage of 1.5g/day.

Subjects consumed 2 portions of bread enriched with free curcumin (1g/100g portion, i.e. 2g/day)

Free Then Encapsulated Curcumin (1 Day)

Washout Period of 1 Week

Encapsulated Then Free Curcumin (1 Day)

Enc Curc + PQG Then Free Polyph. (1 Day)

Free Polyph. Then Enc Curc + PQG (1 Day)

Enc Polyph. Then Control Cream (1 Day)

Control Cream Then Enc Polyph. (1 Day)

Prof. Vincenzo Fogliano

free curcumin in bread, dosage 1g/100g, 200g/day per 1 day

free curcumin

encapsulated curcumin-enriched bread, 1g/100g bread, 200g bread/day

encapsulated curcumin

bread enriched with encapsulated curcumin plus piperine, quercetin and genistein, 1g/100g bread, 200g bread/day

encapsulated curcumin + PQG

nut cream enriched with free cocoa polyphenols, 1,5 g/100g cream, 100g/day per 1 day

free cocoa polyphenol

nut cream enriched with encapsulated cocoa polyphenols, 1,5 g/100g cream, 100g/day per 1 day

anthocyanidin/upala

Antipsychotic Effects of Sorghum Bicolor (JOBELYN) in the Treatment of Schizophrenia

Health Impacts of Sustainable Ingredient Selection in the Food and Drink Industry - ALTERNATIVE PROTEIN STUDY

The Safety and Efficacy of Jobelyn in the Treatment of Breast Cancer Patients

Physiological Effects of New Polyphenol-enriched Foods in Humans

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