The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions containing said compounds and the preparation methods thereof. The invention also relates to the use of the above mentioned compounds in the preparation of drugs for the prophylaxis or treatment of cardiovascular diseases, diabetes, bronchial and urinary smooth muscle spasm as well as ischemic and anoxic nerve injury. The above compounds can be used to treat hypertension, angina diaphragmatic, myocardial infarction, congestive heart failure, arrhythmia, diabetes, spasmodic bronchial diseases, spasmodic bladder or ureter diseases, and depression. ##STR00001##

Institute of Pharmacology and Toxicology Academy of Military Medical Sciences, P.L.A.

Amine derivative with potassium channel regulatory function, its preparation and use

Single- or dual-bladder devices for remote ischemic preconditioning and blood pressure monitoring are disclosed along with various oscillometry-based and other methods for detecting systolic and diastolic blood pressure while the ischemic preconditioning treatment is in progress. The devices and methods of the invention provide for delivery of ischemic preconditioning at the lowest effective cuff pressure while closely monitoring patient's hemodynamics. Advantageously, the device of the invention allows both ischemic preconditioning and blood pressure monitoring to be done on the same limb. Disposable battery-powered version of the device of the present invention is especially useful for emergency use with patients suffering from acute myocardial infarction, acute stroke, or acute trauma. Additional device configurations are described for use in a percutaneous intervention and vascular sealing settings.

Leschinsky; Boris

Infarct Reduction Technologies Inc.

Automatic devices for remote ischemic preconditioning

LifeCuff Technologies Inc.

This invention provides thienopyrimidine derivatives of the formula, ##STR00001## wherein R.sup.1 stands for hydrogen atom, an alkyl group or the like; R.sup.2 stands for a hydrogen atom, an alkyl or amino group or the like, R.sup.3 stands for an alkyl, alkenyl or alkylthio group or the like or a group Y--X--; or R.sup.2 and R.sup.3 may together form tetramethylene group; X standing for a direct bond or linking group such as CH.sub.2, CH(OH), S, O, NH; Y standing for a substituted or unsubstituted aromatic carbocyclic, aromatic heterocylic, cycloalkyl or saturated heterocyclic group or the like; Z stands for S or O, and n is 0 or an integer of 1 to 4, or salts thereof, which exhibit an inhibitory effect on PDE9, and are therefore useful for prevention or treatment of overactive bladder syndrome, pollakiuria, urinary incontinence, dysuria associated with prostatic hyperplasia, urolithiasis, Alzheimer's disease, chronic obstructive pulmonary disease, myocardial infarction, thrombosis, diabetes and the like.

Gotanda; Kotaro

Shinbo; Atsushi

Nakano; Youichi

Kobayashi; Hideo

Okada; Makoto

Asagarasu; Akira

ASKA Pharmaceutical Co., Ltd.

Thienopyrimidine derivatives

This invention provides thienopyrimidine derivatives of the formula, ##STR00001## wherein R.sup.1 stands for hydrogen atom, an alkyl group or the like; R.sup.2 stands for a hydrogen atom, an alkyl or amino group or the like, R.sup.3 stands for an alkyl, alkenyl or alkylthio group or the like or a group Y--X--; or R.sup.2 and R.sup.3 may together form tetramethylene group; X standing for a direct bond or linking group such as CH.sub.2, CH(OH), S, O, NH; Y standing for a substituted or unsubstituted aromatic carbocycylic, aromatic heterocylic, cycloalkyl or saturated heterocyclic group or the like; Z stands for S or O, and n is 0 or an integer of 1 to 4, or salts thereof, which exhibit an inhibitory effect on PDE9, and are therefore useful for prevention or treatment of overactive bladder syndrome, pollakiuria, urinary incontinence, dysuria associated with prostatic hyperplasia, urolithiasis, Alzheimer's disease, chronic obstructive pulmonary disease, myocardial infarction, thrombosis, diabetes and the like.

Aska Pharmaceutical Co., Ltd.

bladder

infarction

bladder/infarction

Amine derivative with potassium channel regulatory function, its preparation and use

Automatic devices for remote ischemic preconditioning

Automatic devices for remote ischemic preconditioning

Thienopyrimidine derivatives

Thienopyrimidine derivatives

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