The invention provides compounds for use in the treatment of a disease or condition selected from brain disorders and triple-negative breast cancer, the compounds being of the formula (1): ##STR00001## or a salt or tautomer thereof; wherein: X.sup.1 is N or N.sup.+(O.sup.-); X.sup.2 is N or CH; Q is selected from a C1-3 alkylene group, cyclopropane-1,1-diyl and cyclobutane-1,1-diyl; R.sup.1 is selected from hydrogen and C.sub.1-4 alkyl; R.sup.2, R.sup.3 and R.sup.4 are the same or different and each is selected from hydrogen and fluorine; Ar.sup.1 is a benzene, thiophene, naphthyl or pyridine ring optionally substituted with 1, 2 or 3 substituents selected from fluorine; chlorine; bromine; C.sub.1-4 hydrocarbyl; C.sub.1-4 hydrocarbyloxy; trifluoromethyl; difluoromethyl; cyano; trifluoromethoxy; difluoromethoxy; Ar.sup.2 is a monocyclic 5- or 6-membered heteroaryl ring containing 1, 2 or 3 heteroatom ring members selected from O, N and S and being optionally substituted with 1, 2 or 3 substituents selected from fluorine; C.sub.1-4 hydrocarbyl; amino; mono-C.sub.1-4 hydrocarbylamino and di-C.sub.1-4 hydrocarbylamino; and wherein, in each substituent consisting of or containing C.sub.1-4 hydrocarbyl, the C.sub.1-4 hydrocarbyl is selected from C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, cyclopropyl, cyclobutyl and cyclopropylmethyl.

bromine/rak dojke

Modulators of the p70S6 kinase for use in the treatment of brain disorders and triple-negative breast cancer

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