We will flush the deceased donor kidney with UW (perfusion solution) + sodium thiosulfate (STS)

Kidney will be flushed with UW (perfusion solution) which is the normal standard of care.

End Stage Renal Disease (ESRD)

The kidney will have 100 mL of 500µM STS added directly to the existing pulsatile perfusion solution at 4°C.

Seacalphyx (sodium thiosulfate pentahydrate injection BP) 25%

London Health Sciences Centre, University Hospital

Evaluation of Thiosulfate in End Stage Renal Disease and Kidney Transplantation

between 1 week and 1 year following transplant

Measuring death of tubular epithelial cells that form the renal tubules of the kidneys.

Patient Urine protein/creatinine ratio results

Patient urinary injury biomarkers (KIM-1/NGAL).

Alp Sener

Principal Investigator

Lawson Health Research Institute

For the purposes of this study we will flush the deceased donor kidney with UW (perfusion solution) or UW + sodium thiosulfate (STS). There will be two groups in the study - UW with or without STS and patients will be randomly assigned to a group in a 1:1 ratio (i.e. 50 in one group and 50 in the other).

calciphylaxis/cistein

Evaluation of Thiosulfate in End Stage Renal Disease and Kidney Transplantation

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