camptotheca acuminata/rak debelog crijeva

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Delivery methods of camptothecin and its hydrosoluble analogue irinotecan for treatment of colorectal cancer.

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Camptothecins are a family of alkaloids originally extracted from the Chinese tree Camptotheca acuminata, Nyssaceae, exhibiting a strong activity against colorectal cancer (CRC). CRC is a common malignancy worlwide. Despite significant developments in the treatment of this disease, it still causes

CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45.

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CIL-102 (1-[4-(furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone) is a well-known, major active agent of the alkaloid derivative of Camptotheca acuminata with valuable biological properties, including anti-tumorigenic activity. In this study, we investigated the molecular mechanisms by which CIL-102

Irinotecan

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Irinotecan is a DNA topoisomerase I inhibitor that received approval for use in the United States in 1996.[1] It is derived from the Chinese tree, Camptotheca acuminata, and is used as a chemotherapy agent against a variety of solid tumors, such as colorectal, pancreatic, ovarian, and lung

Regression of human colon cancer xenografts in SCID mice following oral administration of water-insoluble camptothecins.

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Gastrointestinal cancers pose major public health problems worldwide, in part because little progress has been made in the treatment of colorectal cancers. The present study explored the potential use of natural product topoisomerase I inhibitors, 10-hydroxycamptothecin (HCPT) and camptothecin

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