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Cerium oxide nanoparticles reduce the accumulation of autofluorescent deposits in light-induced retinal degeneration: Insights for age-related macular de generation
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Accumulation of lipofuscin deposits in the retinal pigment epithelium (RPE) is one of the main events involved in age-related macular degeneration and its increase together with RPE dysfunction, blood retinal barrier disruption and photoreceptors death progressively leads to blindness. Lipofuscin is
Improvement of isolated rat pancreatic islets function by combination of cerium oxide nanoparticles/sodium selenite through reduction of oxidative stress.
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Insulin Dependent Diabetes Mellitus (IDDM) is a disease with high incidence with no pure cure therapy yet. In most of cases, these patients need pancreatic islets transplantation that is not completely successful because of oxidative stress happening during isolation and transplantation procedures.
Molecular and electronic structures of cerium and cerium suboxide clusters.
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The anion photoelectron (PE) spectra of Ce2Oy- (y = 1, 2), Ce3Oy- (y = 0-4), Ce4Oy- (y = 0-2), and Ce5Oy- (y = 1, 2) are reported and analyzed with supporting results from density functional theory calculations. The PE spectra all exhibit an intense electronic transition to the neutral ground state,
Attack of hydroxyl radicals to α-methyl-styrene sulfonate polymers and cerium-mediated repair via radical cations.
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Both synthetic polymers (membranes, coatings, packaging) and natural polymers (DNA, proteins) are subject to radical-initiated degradation. In order to mitigate the deterioration of the polymer properties, antioxidant strategies need to be devised. We studied the reactions of poly(α-methylstyrene
Titanium-doped cerium oxide nanoparticles protect cells from hydrogen peroxide-induced apoptosis.
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To develop new nanoparticle materials possessing anti-oxidative capacity with improved physical characteristics, we have studied titanium-doped cerium oxide (CeTiO2) nanoparticles. CeTiO2 nanoparticles had a mode diameter of 15-20 nm. These nanoparticles demonstrated catalase activity, and did not
Using cerium chloride to control soluble orthophosphate concentration and improve the dewaterability of sludge: Part II. A case study.
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High concentration of orthophosphate ion (OP) in anaerobically digested sludge can lead to struvite crystallization, deterioration of sludge dewaterability, and elevated mainstream OP loading through centrate recirculation. The Upper Occoquan Service Authority (UOSA) has observed seasonally high OP
Translocation of intranasal (i.n.) instillation of different-sized cerium dioxide (CeO2) particles: potential adverse effects in mice.
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Cerium oxide (CeO2), one of many engineered nanomaterials (ENMs), is composed primarily of metal oxides, such as cerium oxide (CeO2). CeO2-containing materials are widely used as a polishing agent for glass mirrors, plate glass, television tubes, ophthalmic lenses,
Ophthalmic Applications of Cerium Oxide Nanoparticles.
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Cerium oxide nanoparticles (CeO2-NPs; or nanoceria) have been largely studied for biomedical applications due to their peculiar auto-regenerative antioxidant activity. This review focuses on ophthalmic applications of nanoceria. Many in vivo data indicate that nanoceria protect the
In vivo protective role against water contamination with cerium via chronic administration of omega 3.
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In the present study, adult, healthy male Wistar rats (120 ± 10 g) were pre-treated by intragastric administration of cerium chloride (CeCl3) 10 mg/kg (BW) each day during 60 days. Control animal were treated with omega 3, a polyunsaturated fatty acid (ω-3), by an intragastric administration at 10
Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats.
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BACKGROUND
Cerium oxide (CeO(2)) nanoparticles have been posited to have both beneficial and toxic effects on biological systems. Herein, we examine if a single intratracheal instillation of CeO(2) nanoparticles is associated with systemic toxicity in male Sprague-Dawley rats.
RESULTS
Compared with
Multi-biomarker approach to assess the acute effects of cerium dioxide nanoparticles in gills, liver and kidney of Oncorhynchus mykiss
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Cerium oxide nanoparticles (CeO2-NP) have already been detected in the aquatic compartment, however, the evaluation of potential ecotoxicological effects on biota are scarce. The present study aimed to assess the toxic effects of CeO2-NP in Oncorhynchus mykiss in different
Cerium oxide nanoparticles alleviate oxidative stress and decreases Nrf-2/HO-1 in D-GALN/LPS induced hepatotoxicity.
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Translocation of the master regulator of antioxidant-response element-driven antioxidant gene, nuclear factor erythroid 2 (Nrf-2) from the cytoplasm into the nucleus and triggering the transcription of hemoxygenase-1 (HO-1) to counteract the oxidative stress is a key feature in D-galactoseamine and
Cerium oxide nanoparticle elicits oxidative stress, endocrine imbalance and lowers sperm characteristics in testes of balb/c mice.
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The toxicity of metallic nanoparticles is a growing concern due to its application in industries and homes. We investigated the toxicity of cerium oxide nanoparticles (CeO2 NPs) on reproductive system in male balb/c mice. Twenty mice were divided into four groups of five animals each and treated
Nanoceria-loaded injectable hydrogels for potential age-related macular degeneration treatment.
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The major purpose of this article is to evaluate oligochitosan coated cerium oxide nanoparticles (OCCNPs) alginate laden injectable hydrogels and their potential treatment for age-related macular degeneration (AMD). The water soluble OCCNPs were loaded within injectable hydrogels as antioxidative
Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxides.
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Photoreceptor cells are incessantly bombarded with photons of light, which, along with the cells' high rate of oxygen metabolism, continuously exposes them to elevated levels of toxic reactive oxygen intermediates (ROIs). Vacancy-engineered mixed-valence-state cerium oxide nanoparticles (nanoceria
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