A polymer-coated cerium oxide based device and system is disclosed for detecting reactive oxygen species and monitoring chronic inflammation. The device and system encapsulate free therapeutic nanoparticle elements not present in a living body in a prosthetic or implantable unit. Embodiment one is a two-chamber structure with a reactive oxygen species (ROS) scavenging component on one end and at the opposite end is an imaging agent consisting of at least one of a fluorophore capable of fluorescence emission, a chemiluminescent agent, a magnetic relaxation agent and an X-ray contrast agent. Embodiment two is a single chamber device consisting of a multifunctional nanocomposite with a ROS-scavenging nanoparticle constituent (nanoceria) and a multimodal reporting nanoparticle component (i.e. Dex-IO-DiR). The device and system are utilized in treatment of diseases with a pro-inflammatory component, including, but not limited to, Crohn's disease, ulcerative colitis, inflammatory bowel disease, cystic fibrosis, arthritis, and cancer chemotherapy.

Perez; Jesus Manuel

Kaittanis; Charalambos

Asati; Atul

Santra; Santimukul

University of Central Florida Research Foundation, Inc.

Cerium oxide nanoparticle-based device for the detection of reactive oxygen species and monitoring of chronic inflammation

Cerium-oxide nanoparticle based device for the detection of reactive oxygen species and monitoring of chronic inflammation

The present invention provides cerium oxide nanoparticles for use both in therapeutic compositions in vivo and in research in vitro. The cerium oxide nanoparticles are of known range of sizes having biological properties that are reproducible and beneficial. Pharmaceutical and other compositions are provided, as are methods of treatment.

Rzigalinski; Beverly A.

Clark; Ariane M.

Anti-inflammatory, radioprotective, and longevity enhancing capabilities of ceriumoxide nanoparticles

Methods for treating sepsis are provided and include the administration an effective amount of cerium oxide nanoparticles to a subject in need thereof. The sepsis being treated can include polymicrobial sepsis and can include the administration of about 0.1 mg/kg to about 1.0 mg/kg of the cerium oxide nanoparticles. The administration of the cerium oxide nanoparticles further allows one or more of the symptoms of sepsis to be treated. Methods of treating an inflammatory disorder that make use of cerium oxide nanoparticles are further provided.

cerium/upala

Cerium oxide nanoparticle-based device for the detection of reactive oxygen species and monitoring of chronic inflammation

Cerium-oxide nanoparticle based device for the detection of reactive oxygen species and monitoring of chronic inflammation

Anti-inflammatory, radioprotective, and longevity enhancing capabilities of ceriumoxide nanoparticles

Methods for treating sepsis

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