chorioamnionitis/albumin

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Effect of chorioamnionitis on the levels of serum proteins in the cord blood of premature infants.

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OBJECTIVE To determine the relationships among complements, other serum proteins (including acute-phase reactant), and the cytokine interleukin-6. METHODS Prospective observational study. METHODS A perinatal center, children's hospital, and research institute in Osaka, Japan. METHODS Two hundred

Randomized, blind trial of dopamine versus dobutamine for treatment of hypotension in preterm infants with respiratory distress syndrome.

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To compare the efficacy of dopamine and dobutamine for the treatment of hypotension (mean arterial blood pressure, < or = 30 mm Hg) in preterm (< or = 34 weeks of gestation) infants with respiratory distress syndrome in the first 24 hours of life, we enrolled 63 hypotensive preterm infants in a

Occult inflammation and/or ischemia may be responsible for the false positivity of biochemical Down syndrome screening test.

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OBJECTIVE To determine the possible underlying cause of a false-positive first or second trimester biochemical Down syndrome screening test result by means of second trimester amniotic fluid cytokine level analysis. METHODS A total of 74 consecutive patients undergoing amniocentesis for karyotype

Bronchoalveolar lavage in ventilated newborn infants: safety and tumor necrosis factor-alpha activity.

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OBJECTIVE To investigate the safety of bronchoalveolar lavage (BAL) in sick ventilated preterm and term newborn infants. METHODS We studied 32 preterm and term newborn infants on mechanical ventilation during the first week of life. BAL was done through blind wedging of a suction catheter into the

Increased leukocyte elastase of the tracheal aspirate at birth and neonatal pulmonary emphysema.

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OBJECTIVE The authors have previously shown the association of elevated neonatal serum IgM and chorioamnionitis in infants in whom pulmonary emphysema characteristic of Wilson-Mikity syndrome subsequently developed. This paper extends the observation to the measurement of polymorphonuclear leukocyte

Monocytosis in preterm infants.

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In sick preterm neonates receiving intensive care a spectacular rise in monocyte count has frequently been observed in sequential full blood examinations. The etiology of this has not previously been investigated and this study examines clinical factors that may contribute to this finding. Thirty

Surfactant Components and Tracheal Aspirate Inflammatory Markers in Preterm Infants with Respiratory Distress Syndrome.

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In 93 preterm infants ≤32 weeks of gestational age and 12 control infants, epithelial lining fluid disaturated-phosphatidylcholine, surfactant protein A and B, albumin, and myeloperoxidase activity were assessed after intubation and before exogenous surfactant administration. We found that

Prenatal Intra-Amniotic Endotoxin Induces Fetal Gut and Lung Immune Responses and Postnatal Systemic Inflammation in Preterm Pigs.

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Prenatal inflammation is a major risk for preterm birth and neonatal morbidity, but its effects on postnatal immunity and organ functions remain unclear. Using preterm pigs as a model for preterm infants, we investigated whether prenatal intra-amniotic (IA) inflammation modulates postnatal systemic

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