cratoxylum/antifungik

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Anti-Proliferation and Apoptosis Induction in Breast Cancer Cells by Cratoxylum cochinchinense Extract.

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Breast cancer is the most common invasive cancer in females worldwide. It was found about 37.5% in Thai females and is one of the leading causes of death-related cancers in women. Therefore, new finding of anti-cancer compound as a therapeutic candidate in breast cancer is necessary. To investigate

Caged-xanthone from Cratoxylum formosum ssp. pruniflorum inhibits malignant cancer phenotypes in multidrug-resistant human A549 lung cancer cells through down-regulation of NF-κB.

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Our recent study reported that multidrug-resistant (MDR) human A549 lung cancer cells (A549RT-eto) with the elevated expression of NF-κB showed epithelial-mesenchymal transition (EMT), increasing spheroid formation and elevating the expression levels of stemness-related factors, including Oct4,

Chromene and prenylated xanthones from the roots of Cratoxylum formosum ssp. pruniflorum.

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Two new xanthones, namely pruniflorone K (1) and L (2), have been isolated from the roots of Cratoxylum formosum ssp. pruniflorum, along with thirteen known xanthones (3-15). Their structures were mainly established using the spectroscopic methods. Only isolated compounds with sufficient amount were

Targeting truncated retinoid X receptor-α by CF31 induces TNF-α-dependent apoptosis.

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A truncated version of retinoid X receptor-α, tRXR-α, promotes cancer cell survival by activating the phosphoinositide 3-kinase (PI3K)/AKT pathway. However, targeting the tRXR-α-mediated survival pathway for cancer treatment remains to be explored. We report here our identification of a new natural

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