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Stranica 1 iz 967 rezultatima
Phosphocreatine protects transgenic mouse liver expressing creatine kinase from hypoxia and ischemia.
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Creatine kinase (CK) is normally found at high levels in muscle and brain and catalyzes the reaction phosphocreatine (PCr) + MgADP + H+<==>creatine (Cr) + MgATP. CK is not normally found at high levels in liver. A line of transgenic mice that express high levels of the BB-dimer of CK (CKB) in liver
Protective effects of some creatine derivatives in brain tissue anoxia.
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Some derivatives more lipophylic than creatine, thus theoretically being capable to better cross the blood-brain barrier, were studied for their protective effect in mouse hippocampal slices. We found that N-amidino-piperidine is harmful to brain tissue, and that phosphocreatine is ineffective.
Involvement of the phosphoryl transfer network in gill bioenergetic imbalance of pacamã (Lophiosilurus alexandri) subjected to hypoxia: notable participation of creatine kinase.
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Hypoxia is among the most critical environmental stressors for fish in aquatic environments, and several energetic alterations have been associated with it. The aim of the present study was to evaluate the involvement of the phosphoryl transfer network and its effects on adenosine triphosphate
Is the neonatal creatine phosphokinase level a reliable marker for fetal hypoxia?
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OBJECTIVE
The creatine phosphokinase (CPK) level is believed to increase in neonatal peripheral blood after tissue damage, including damage from perinatal hypoxia. However, it is not clear whether it is truly a reliable marker for fetal hypoxia. We investigated the chronological changes in neonatal
Adaptation of cardiac myosin and creatine kinase to chronic hypoxia: role of anorexia and hypertension.
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The effects of chronic hypobaric hypoxia (CHH, 28 days, simulated altitude 5,500 m) on the cardiac expression of myosin heavy chain (MHC) and creatine kinase (CK) was studied in rat left (LV) and right (RV) ventricle. To separate the effects of hypoxia from its associated perturbations, anorexia and
Appearance of a cathodic band in the electrophoretogram of blood creatine kinase isoenzyme-MM fraction during hypoxia in rats.
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In electrophoretograms of creatine kinase (CK; EC 2.7.3.2) in patients' blood, a band, presumably of mitochondrial origin, is occasionally observed on the cathodic side of the CK-MM fraction. We studied the implications of this phenomenon in rats exposed to hypoxic conditions. In the hypoxic cardiac
Effects of coenzyme Q10 on recovery of hypoxia-induced changes in ATP and creatine phosphate contents of sinoatrial nodal cells of the rabbit's heart after reoxygenation.
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We have studied the effects of reoxygenation on hypoxia-induced changes in contents of high energy phosphate compounds in pacemaker cells of nodal tissues excised from the rabbit heart, and effects of coenzyme Q10 on the electrical activity and metabolite contents in the tissue exposed to hypoxia
[Behavior of creatine in red blood cells and blood plasma of adult rats following exposure to hypoxia].
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Adults rats exposed to hypoxia showed a definite increase of creatine concentration in red cells and plasma. The rise in cell creatine 37 h after the beginning of hypoxia had disappeared 2 days after the end of hypoxia. It is explained by the expulsion of preformed reticulocytes from the bone
Creatine and density of red blood cells in perinatal hypoxia.
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Signs of stimulated erythropoiesis, such as increased creatine and decreased density of red cells are good indicators of hypoxemia in adults and older children. The sensitivity of both tests in perinatal hypoxia was found to be reduced. The causes for this reduction were investigated.
Creatine in density-fractionated red cells, a useful indicator of erythropoietic dynamics and of hypoxia past and present.
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Creatine in density-fractionated red cells is not only a useful criterion of cell age but also an excellent indicator of erythropoietic dynamics particularly under the influence of present and past hypoxia. This is documented on patients with cardiac hypoxia. A histogram is proposed which permits
Increased creatine kinase BB activity in rat plasma induced by hypoxia.
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Rats show an elevated creatine kinase (CK) activity in plasma after a 20-hour exposure to hypoxia. The increase of CK activity is essentially caused by CK-BB activity attaining its maximum at the 3rd day after exposure to hypoxia. The possibility of establishing a potential brain damage by
[Effects of freezing and hypoxia on serum creatine kinase activity in rats].
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Serum creatine kinase (CK) activity after cold exposure in rats acclimated to cold, hypoxia, or combined factors (both cold and hypoxia) were observed under normoxic [correction of normoxie] and hypoxic condition in order to study the degrees of damage to the tissues. The results showed that
Effect of creatine monohydrate supplementation on various hematological and serum biochemical parameters of male albino mice following neonatal hypoxia-ischemia encephalopathy.
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BACKGROUND
Present study was designed to report the effect of 2% creatine monohydrate supplementation for 8, 12 and 15 weeks on hematology and serum biochemical profile of male albino mouse following hypoxic ischemic insult on postnatal day 10.
METHODS
66 Blood samples (2% creatine monohydrate
Chronic hypoxia enhances expression and activity of mitochondrial creatine kinase and hexokinase in the rat ventricular myocardium.
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BACKGROUND
Creatine kinase (CK) and hexokinase (HK) play a key role in myocardial energy homeostasis. We aimed to determine CK and HK expression and enzyme activity in the left (LV) and right (RV) ventricles of rats adapted for 3 weeks to normobaric hypoxia (10 % O2) either continuously (CNH) or
Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation.
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Creatine (Cr), phosphocreatine (PCr), and creatine kinases (CK) comprise an energy shuttle linking ATP production in mitochondria with cellular consumption sites. Myocytes cannot synthesize Cr: these cells depend on uptake across the cell membrane by a specialized creatine transporter (CrT) to
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