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cycleanine/chagasova bolest
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2 rezultatima
The effect of bisbenzylisoquinoline alkaloids on Trypanosoma cruzi infections in mice.
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Prijava Registriraj se
Five bisbenzylisoquinoline (BBI) alkaloids, curine, cycleanine, isotet:andrine, limacine and pheanthine were tested for trypanocidal activity in C 3H He mice infected with Y or CL strain of Trypanosoma cruzi. The activity was compared with the baseline drug, benznidazole. Oral treatment was more
Trypanocidal bisbenzylisoquinoline alkaloids are inhibitors of trypanothione reductase.
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Prijava Registriraj se
Eleven bisbenzylisoquinoline (BBIQ) alkaloids were studied for in vitro trypanocidal activity against trypomastigote forms of the Y strain of Trypanosoma cruzi. The inhibitory activity of these compounds against trypanothione reductase (TR), a target enzyme for chemotherapy against Chagas disease,
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